International Journal of Hematology-Oncology and Stem Cell Research 2016. 10(1):56-60.

A patient with Multiple myeloma and Renal cell carcinoma
Farhad Shahi, Marziye Ghalamkari, Mehrzad Mirzania, Mahdi Khatuni


 The coexistence of two malignancies is rarely seen. A little association between hematologic malignancies especially multiple myeloma and renal cell carcinoma has been reported in the recent past. Several case series revealed a bidirectional association between these two malignancies which may be due to the common risk factors, similar cytokine growth requirements and clinical presentation. Here, we aim to describe a patient who had multiple myeloma and in his work up renal cell carcinoma was found out incidentally. We would like to create awareness among clinicians for the coincidence of Renal cell carcinoma and Multiple myeloma.


Multiple myeloma; Renal cell carcinoma; Secondary hematologic malignancy

Full Text:



Munchi N, Longo D, Anderson K. Plasma cell disorders In: Kasper D, Fauci A, Hauser S, et al. Harrison principles of internal medicine, 19th ed. Mc Graw Hill pub. 2015,712.

Kaushansky K, Lichman M, Beutler E, et al. Williams Hematology, 8th ed, E book, 2010; 2120.

Scher H, Rosenberge J, Motzer R. Bladder and renal cell carcinoma. In: Kasper D, Fauci A, Hauser S, Longo D, et al. Harrison principles of internal medicine, 19th ed. Mc Graw Hill pub. 2015; 578.

Bhandari MS, Mazumder A, Jagannath S, et al. Association between renal cell carcinoma and plasma cell dyscrasia. Clin lymphoma myeloma. 2008; Vol 8, No 3: 188-190.

Sakai A, Kawano M, Kuramoto A. Interleukin 6 produced by renal cell carcinoma cells and progression of MM. N Engl J Med. 1991; 324: 1893-4.

Ojha RP, Evans EL, Felini MJ, et al. The association between renal cell carcinoma and multiple myeloma: insights from population-based data. BJU Int. 2011 Sep; 108 (6): 825-30.

Greer J, Arber D, Glader B, et al. Wintrobe’s clinical hematology, 13th edition. 2014; 2092.

Sehgal T, Sharma S, Naseem S, et al. Synchronous occurrence of prostate carcinoma and multiple myeloma: a case report. Indian J Hematol Blood transfuse. 2014 sep; 30 (Suppl 1): 359-362.

Dutcher J, Wiernik P. Renal cell carcinoma in patients with a personalor family history of hematologic malignancy. Clin Adv Hematol Oncol. 2015; Vol 13, No (6): 392-397.

Padhi S, Mokkapan S, Varghese R, et al. Plasmablastic multiple myeloma following clear cell renal cell carcinoma. BMJ Case Rep. 2014; 10.

Badros A, Karakunnel J, Dawson N. Multiple myeloma and renal cell carcinoma possible association. Leukemia and Lymphoma. 2007; 48: 1662-4.


  • There are currently no refbacks.

Creative Commons Attribution-NonCommercial 3.0

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.