International Journal of Hematology-Oncology and Stem Cell Research 2014. 8(1):41-5.

A 34 year old man with purple discoloration and paresthesia.
Aida Iranpour, Reihaneh Mahmoodian, Anoosheh Haghighi, Masoud Vakili, Ali Shahriari-Ahmadi, Shokoufeh Hajsadeghi, Mohsen Arabi


Secondary systemic vasculitis and nonbacterial endocarditis are rare events. We report a case presented with different manifestations of underlying malignancy such as systemic vasculitis, non bacterial endocarditis and DIC (disseminated intravascular coagulopathy). Efforts to find the source of malignancy was unsuccessful and due to patient's unwillingness for further evaluation, finally under the diagnosis of metastatic disease of unknown primary, patient is receiving cyclic chemotherapy.


Marantic endocarditis; Systemic vasculitis

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Jennette JC, Falk RJ, Andrassy K, et al. (1994) Nomenclature of systemic vasculitides. Arthritis and Rheum 37:187–192

Pagnoux C, Cohen P, Guillevin L. Vasculitis secondary to infections. Clin Exp Rheumatol. 2006;24(suppl 2):S71-S81.

Kraemer M, Berlit P: Systemic, secondary and infectious causes for cerebral vasculitis: clinical experience with 16 new European cases. Rheumatol Int 2009 Oct 13 (Epub ahead of print).

Calabrese LH, Duna GF, Lie JT: Vasculitis in the central nervous system. Arthritis Rheum 1997, 40:1189–1201.

Minagar A, Fowler M, Harris MK, Jaffe SL: Neurologic presentations of systemic vasculitides. Neurol Clin 2010, 28:171–184

S. Asopa, A. Patel, O. Khan, R. Sharma, S. Ohri,Review: non-bacterial thrombotic endocarditisEur J Cardio-thorac Surg, 32 (2007), pp. 696–701

Y. Edoute, N. Haim, D. Rinkevich, B. Brenner, S.A. Reisner,Cardiac valvular vegetations in cancer patients: a prospective echocardiographic study of 200 patients

V. Markides, P. Nihoyannopoulos,Non-bacterial thrombotic endocarditis,Eur J Echocardiogr, 1 (2000), pp. 291–294

Deitcher SR. Cancer and thrombosis: mechanisms and treatment. J Thromb Thrombolysis. 2003;16(1-2):21-31

Dvorak HF. Abnormalities of hemostasis in malignant disease. In: Colman RW, Hirsh J, Marder VJ et al., eds. Hemostasis and Thrombosis. Philadelphia: J. B. Lippincott, 1994:1238-1254

Gross L, Friedberg CK. Nonbacterial thrombotic endocarditis. Classification and general description. Arch Intern Med 1936;58:620-640.

Steiner I. Nonbacterial thrombotic endocarditis--a study of 171 case reports. Cesk Patol. 1993;29(2):58-60.

Bedikian A, Valdivieso M, Luna M, Bodey GP. Nonbacterial thrombotic endocarditis in cancer patients: comparison of characteristics of patients with and without concomitant disseminated intravascular coagulation. Med Pediatr Oncol. 1978;4(2):149-157

Ojeda VJ, Frost F, Mastaglia FL. Non-bacterial thrombotic endocarditis associated with malignant disease: a clinicopathological study of 16 cases. Med J Aust. 1985;142(12):629-631

Kooiker JC, MacLean JM, Sumi SM. Cerebral embolism, marantic endocarditis, and cancer. Arch Neurol. 1976;33(4):260-264


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