Primary Vaginal Chloroma: A Rare Case Report

  • Irappa Madabhavi Department of Medical and Paediatric Oncology, Kerudi Cancer Hospital, Bagalkot, Karnataka, India
  • Apurva Patel Department of Medical and Paediatric Oncology, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India
  • Mitul Modi Department of Pathology, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India
  • Swaroop Revannasiddaiah Department of Radiotherapy, Government Medical College, Haldwani, India
  • Chidanand Chavan Department of Medical and Paediatric Oncology, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India
Keywords: Chloroma, Myeloid sarcoma, Patient, Decitabine


Chloroma (granulocytic sarcoma or myeloid sarcoma) is a rare malignant extra-medullary neoplasm of myeloid precursor cells. It is usually associated with myeloproliferative disorders but very rarely may precede the onset of leukaemia. Here we are presenting a rare case of chloroma in  a female patient without initial presentation of AML. 38 year old female patient, with performance score-1 had complaining of per vaginal bleeding for 1-2 days. Patient consulted gynaecologist and underwent biopsy from anterior fornix of vagina. Biopsy material was positive for LCA (leukocyte common antigen), MPO (myeloperoxidase), c-kit positive on IHC (immunohistocytochemistry) while negative for cytokeratin, synaptophysin, chromogranin, CD20 (cluster of differentiation. Whole body CT scan was non informative except mass lesion at vagina. Patient was given 3+7 induction chemotherapy which was tolerated well followed by high dose cytarabine as consolidation therapy.


Reardon G, Moloney WC. Chloroma and related myeloblastic neoplasms. Arch Intern Med. 1961; 108: 864-71.

Neiman RS, Barcos M, Berard C, et al. Granulocytic sarcoma: a clinicopathologic study of 61 biopsied cases. Cancer.1981; 48(6):1426-37.

Oliva E, Ferry JA, Young RH, et al. Granulocytic sarcoma of the female genital tract: a clinicopathologic study of 11 cases. Am J Surg Pathol. 1997; 21(10):1156-65.

Pathak B, Bruchim I, Brisson ML, et al. Granulocytic sarcoma presenting as tumors of the cervix. Gynecol Oncol. 2005; 98(3):493-7.

Lan TY, Lin DT, Tien HF, et al. Prognostic factors of treatment outcomes in patients with granulocytic sarcoma. Acta Haematol. 2009; 122(4):238-46.

Burnett AK, Milligan D, Prentice AG, et al. A comparison of low-dose cytarabine and hydroxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fit for intensive treatment. Cancer. 2007; 109(6):1114-24.

Tilly H, Castaigne S, Bordessoule D, et al. Low-dose cytarabine versus intensive chemotherapy in the treatment of acute nonlymphocytic leukemia in the elderly. J Clin Oncol .1990; 8(2):272-9.

Lübbert M, Rüter BH, Claus R, et al. A multicenter phase II trial of decitabine as first-line treatment for older patients with acute myeloid leukemia judged unfit for induction chemotherapy. Haematologica. 2012; 97(3):393-401.

Modi G, Madabhavi I, Panchal H, et al. Primary vaginal myeloid sarcoma: a rare case report and review of the literature. Case Rep Obstet Gynecol. 2015; 2015:957490.

How to Cite
Madabhavi I, Patel A, Modi M, Revannasiddaiah S, Chavan C. Primary Vaginal Chloroma: A Rare Case Report. Int J Hematol Oncol Stem Cell Res. 12(3):165-167.
Case Report(s)