International Journal of Hematology-Oncology and Stem Cell Research 2016. 10(4):236-238.

Secondary ALL after Successful Treatment of Ewing's Sarcoma: A Case Report
Kourosh Goudarzi Pour, Samin Alavi, Shahin Shamsian, Roxana Aghakhani, Mohammad Taghi Arzanian, Hesameddin Hoseini Tavassol, Zahra Eydian, Reyhaneh Kazemi


Treatment with intensification of chemotherapy using alkylating agents and Topoisomerase II inhibitors and radiotherapy has improved the outcome of patients with solid tumors such as Ewing’s sarcoma. However, there are several reports of secondary malignancy following treatment of these tumors. In this article, we describe a 12 years old girl with ALL who had Ewing’s sarcoma when she was 8 years old and underwent successful treatment but after two and half years at 12 years old, she came back with pallor and muscular pain.


Chemoradiotherapy; Leukemia; Ewing sarcoma

Full Text:



De Vathaire F, François P, Hill C, et al. Role of radiotherapy and chemotherapy in the risk of second malignant neoplasms after cancer in childhood. Br J Cancer.1989; 59(5):792-6.

Kony SJ, de Vathaire F, Chompret A, et al. Radiation and genetic factors in the risk of second malignant neoplasms after a first cancer in childhood. Lancet. 1997; 350(9071):91-5.

Kapoor G, Bajpai S, Nair CN, et al. CALLA positive acute lymphoblastic leukemia after Etoposide-based therapy for Ewing’s sarcoma. Leuk Res. 1995; 19(10):771-2.

Secker-Walker LM, Stewart EL, Todd A. Acute lymphoblastic leukemia with t(4;11) following neuroblastoma: a late effect of treatment. Med Pediatr Oncol. 1985; 13(1):48-50.

Hawkins MM, Wilson LM, Stovall MA, et al. Epipodophyllotoxins, alkylating agents, and radiation and risk of secondary leukemia after childhood cancer. BMJ. 1992; 304(6832):951-8.

Nichols CR, Breeden ES, Loehrer PJ, et al. Secondary leukemia associated with a conventional dose of Etoposide: review of serial germ cell tumor protocols. J Natl Cancer Inst. 1993; 85(1):36-40.

Mertens AC. Causes of mortality in survivors of childhood cancer. Pediatr Blood Cancer 2007; 48(7):723-6.

Neglia JP, Friedman DL, Yasui Y, et al. Second malignant neoplasms in five year survivors of childhood cancer: Childhood cancer survivor study. J Natl Cancer Inst. 2001; 93(8):618-29.

Vasudevan V, Cheung MC, Yang R, et al. Pediatric Solid Tumors and Second Malignancies: Characteristics and Survival Outcomes. J Surg Res. 2010; 160(2):184-9.

Kuttesch JF Jr, Wexler LH, Marcus RB, et al. Second malignancies after Ewing’s sarcoma: radiation dose-dependency of secondary sarcomas. J Clin Oncol. 1996; 14(10):2818-25.

Navid F, Billups C, Liu T, et al. Second cancers in patients with the Ewing sarcoma family of tumors. Eur J Cancer. 2008; 44(7): 983-91.

Hawkins MM, Draper GJ, Kingston JE. Incidence of second primary tumors among childhood cancer survivors. Br J Cancer. 1987; 56(3):339-47.

Newton WA Jr, Meadows AT, Shimada H, et al. Bone sarcomas as second malignant neoplasms following childhood cancer. Cancer. 1991; 67(1):193-201.

Tucker MA, Meadows AT, Boice JD Jr, et al. Leukemia after therapy with alkylating agents for childhood cancer. J Natl Cancer Inst. 1987; 78(3):459-64.


  • There are currently no refbacks.

Creative Commons Attribution-NonCommercial 3.0

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.