Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 14 4 2020 10 07 265 273 EN Hojat Shahraki Department of Hematology and Blood Transfusion, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran Akbar Dorgalaleh Department of Hematology and Blood Transfusion, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran Majid Fathi Department of Medical Biotechnology, School of Allied Medicine, Iran University of Medical Sciences. Tehran- Iran Shadi Tabibian Department of Hematology and Blood Transfusion, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran Shahram Teimourian Department of Medical Genetics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Hasan Mollanoori Department of Medical Genetics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Alireza Khiabani School of Medicine, Bam University of Medical Sciences, Bam, Iran Farhad Zaker Department of Hematology and Blood Transfusion, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran 2019 11 04 2020 09 22 Abstract Congenital factor XIII (FXIII) deficiency is an extremely rare bleeding disorder (RBD) with estimated prevalence of one per 2 million in the general population. The disorder causes different clinical manifestations such as intracranial hemorrhage (ICH), recurrent miscarriage, umbilical cord bleeding, etc. High incidence of the disorder might be due to founder effect. To assess founder effect, haplotype analysis is an important step. For this purpose, suitable and reliable genetic markers such as microsatellites (Hum FXIII01 and HumFXIIIA02) and single nucleotide polymorphisms (SNP) are suggested. In the present study we tried to describe evaluation of founder effect in patients with congenital FXIII deficiency via haplotype analysis using suitable genetic markers. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1206 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/1206/868