Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 15 2 2021 04 11 90 95 Hosna Sarani Genetics of Non-communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran 2) Children and Adolescent Health Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran Behrouz Molashahi Genetics of Non-communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran Mohsen Taheri 1) Genetics of Non-communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran 2) Department of Genetic, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran Gholamreza Bahari Children and Adolescent Health Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran Seyed Mahdi Hashemi Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran Mohammad Hashemi Genetics of Non-communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran Saeid Ghavami Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada 2020 05 05 2020 09 17 Introduction: Lymphoma is a common hematopoietic cancer. Immunosuppression is one of the main risk factors for the development of lymphoma. The interleukin (IL)-1 receptor antagonist IL1RN, which binds to the IL-1 receptor, moderates a variety of immune responses related to IL-1. We aimed to assess the impact of IL1RN variable number of tandem repeats (VNTR) polymorphism on lymphoma risk in an Iranian population sample. Materials and Methods: DNA was extracted from peripheral blood of 120 subjects with non-Hodgkin Lymphoma (NHL), 50 subjects with Hodgkin’s lymphoma (HL), and 186 unre­lated healthy individuals. IL1RN VNTR polymorphism was detected using polymerase chain reaction. Results: Our findings revealed that the IL1RN VNTR polymorphism was associated with protection against NHL (P≤0.001, OR: 0.30, 95% CI: 0.18-0.53). The IL1RN 2 allele significantly decreased the risk of NHL (p = 0.023, OR = 0.66, 95%CI = 0.46–0.93). In addition, we found that IL1RN 1/2 was associated with a lower risk of HL (p ≤0.001, OR = 0.24, 95%CI = 0.12–0.50). Conclusion: Our results suggest that the presence of IL1RN VNTR polymorphism is associated with a decreased risk of lymphoma in an Iranian subpopulation in southeast Iran.        https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1326 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/1326/872