Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 18 2 2024 04 16 202 205 Aida Zaghdoudi Department of Infectious Diseases, Clermont-Ferrand University Hospital, Clermont-Ferrand, France Hajer Harrabi 1) Department of Infectious Diseases, Hospital la Rabta, Tunis, Tunisia 2) Faculty of Medicine, Université de Tunis El Manar, Tunis, Tunisia Hanene Tiouiri Benaissa 1) Department of Infectious Diseases, Hospital la Rabta, Tunis, Tunisia 2) Faculty of Medicine, Université de Tunis El Manar, Tunis, Tunisia 2021 08 13 2021 11 10 Kaposi’s sarcoma (KS) and multicentric Castleman's disease (MCD) are both linked to human herpesvirus-8 (HHV-8) infection which most commonly affects people living with human immunodeficiency virus (HIV).  Herein, we describe the case of a 57-year-old patient who has been admitted for fever, night sweats, weight loss, and diffuse lymphadenopathy with abdominal pain. HIV status was confirmed by a positive Western blot test. His initial CD4 cell count was equal to 270 cells/µL. A histological study of a peripheral lymph node concluded that KS is associated with MCD. These two conditions found in the same patient highlight the malignant potential of HHV-8, particularly in the case of HIV-induced immunodeficiency. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1691 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/1691/1033