Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 17 3 2023 07 20 220 223 Hamidreza Soltani Deparement of Rheumatology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Saeb Taghizade Department of Biology, Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran Abdolrahim Sadeghi Department of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Ali Farahat Department of Hematology and Oncology٫ Shahid Sadoughi University of Medical Sciences٫Yazd٫ Iran Mohammad Bagher Owlia Deparement of Rheumatology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 2022 04 11 2023 07 01 Since December 2019 and the global epidemic of COVID-19 different countries have focused on vaccines, and one of the inactivated produced vaccines was the Sinopharm COVID-19 vaccine. Some side effects of this vaccine were reported previously, including pain at the vaccination site, fatigue, lethargy, headache, and tenderness, which were more prevalent among individuals <49 years old. Herein, we reported two patients aged 45 and 51 years old. Both patients have different signs and symptoms after receiving the second dose of the vaccine. None had a history of chronic disease. On examination and following labs and other diagnostic investigations, we found megaloblastic anemia due to atrophic gastritis and low intrinsic factor. These cases showed an autoimmune side effect of the Sinopharm COVID-19 vaccine that was previously reported with an exact mechanism but other features called Covid Arm, Guillain-Barré syndrome, and thrombocytopenia. The mechanism of this reaction is unclear yet. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1822 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/1822/994