Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 18 4 2024 10 12 Sequential Occurrence of Eosinophilic Gastrointestinal Disease in a Case of Waldenström’s Macroglobulinemia in Remission: An Unusual Report with Review 412 415 Ankit Jitani Apollo CBCC Cancer Care, Ahmedabad, Gujarat, India Mayur Mundhe Apollo CBCC Cancer Care, Ahmedabad, Gujarat, India Kazi Husain Apollo CBCC Cancer Care, Ahmedabad, Gujarat, India Hemant Menghani Apollo CBCC Cancer Care, Ahmedabad, Gujarat, India Maharshi Desai Apollo Hospitals International Ltd, Ahmedabad, Gujarat, India Velu Nair Apollo CBCC Cancer Care, Ahmedabad, Gujarat, India 2023 03 28 2023 12 09 Waldenström macroglobulinemia (WM) is a rare lymphoproliferative malignancy presenting with para-proteinemia. The symptoms are attributable to both lymphoproliferation and IgM flare. Gastrointestinal manifestations are not uncommon. It is an indolent disease with good response to chemoimmunotherapy but with possible persistence of asymptomatic paraproteinemia. Resurgence of gastrointestinal symptoms in a patient of WM maintaining reasonable response warrant a thorough search for alternate pathology. Herein we describe a rare case of sequential occurrence of WM with Eosinophilic Gastrointestinal Disease posing a diagnostic and therapeutic challenge. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/2004 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/2004/1059