Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 18 2 2024 04 16 206 209 Wajeeha Aiman Saint Michael’s Medical Center, New York College of Medicine, Newark, NJ, USA Muhammad Ashar Ali Saint Clare’s and St. Mary’s General Hospital, Denville, NJ, USA Navjot Grewal Saint Michael’s Medical Center, New York College of Medicine, Newark, NJ, USA Nyan Bethel Saint Michael’s Medical Center, New York College of Medicine, Newark, NJ, USA Andreas Savopoulos Saint Michael’s Medical Center, New York College of Medicine, Newark, NJ, USA Gunwant Guron Saint Michael’s Medical Center, New York College of Medicine, Newark, NJ, USA 2023 04 03 2024 03 26 Patients with human immunodeficiency virus (HIV) infection have an increased likelihood of venous thromboembolism (VTE) owing to factors such as acquired protein C and S deficiency, antiphospholipid antibody syndrome, and heightened levels of pro-inflammatory cytokines. This case report highlights an exceptionally uncommon occurrence of deep venous thrombosis in an HIV-infected patient receiving a therapeutic dose of enoxaparin. This underscores the need for cautious consideration of the risk of VTE in HIV-infected individuals, even with preventive or therapeutic anticoagulant treatment. Further research is recommended to investigate HIV as a potential risk factor for prophylactic anticoagulation.   https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/2009 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/2009/1034