Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 3 2 2009 06 15 31 32 Shahrbanou Keyhanian Hematology-Oncology department, School of Medicine, Islamic Azad University, Tonekabon, Mazandaran, Iran MM Saravi Radiology Department, Imam Sajjad Hospital, Ramsar, Mazandaran, Iran H Yusefi School of Medicine, Islamic Azad University, Tonekabon, Mazandaran, Iran Z Fotokian School of Nursing and Midwifery, Ramsar, Babol Medical Sciences university, Mazandaran, Iran 2015 10 01 Castleman disease (CD) is a rare, lymphoproliferative disorder of uncertain etiology. We are reporting on two cases of Castleman disease. Both patients were female. This disease can be found wherever lymph nodes are present. We have reported two unusual cases of Castleman disease. A 29- year old woman was referred for evaluation because of a cervical lymph node, weight loss and night sweats. There was a history of Hodgkin’s disease. A 80- year old woman was referred to the oncology clinic because of progressive generalized pruritus and vertigo, weight loss, night sweats and fever. In two cases, a biopsy of the cervical lymph node revealed a plasma cell variant of Castleman disease. CD can present symptoms in patients. Therefore, clinical, hematological and histological features of lymph node revealed a plasma cell variant which can be suggestive of Castleman disease. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/214 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/214/207