Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 3 3 2009 09 15 14 16 M Hadjibabaie Clinical Pharmacology Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Masoud Iravani Hematology- Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Ahmad Reza Shamshiri Epidemiology and Biostatistics Department, Faculty of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran Z Zaker Clinical Pharmacology Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran A Mousavi Hematology- Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Kamran Alimoghaddam Hematology- Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran E Kalantar Immunology Department, Iran University of Medical Sciences, Tehran, Iran M Mojtahedzadeh Clinical Pharmacology Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Ardeshir Ghavamzadeh Hematology- Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran 2015 10 01 Introduction: Zinc (Zn) deficiency can cause significant defects in cellular immunity. Hematopoietic stem cell transplantation (HSCT) patients usually experience serious deficiencies of all components of the immune system. Therefore, the maintenance of a normal Zn status may be important in this group of patients. Patients and Methods: Serum Zn levels were analyzed in 55 patients during the HSCT period. As Zn-related factors, serum copper (Cu) levels and alkaline phosphatase (ALP) activity were also measured. Results: There was decrease in Zn values immediate post-transplant period (at day +10) when compared to pre-HSCT levels (P=0.06). In patients who developed hypozincemia, adverse events appeared to occur more frequently. Conclusion: This study suggests that maintaining a normal Zn status can be important in HSCT patients and Zn deficiency may be a risk factor causing adverse effects. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/218 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/218/211