Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 19 3 2025 07 21 237 247 Alireza Sadeghi Moghaddam Bijari Department of Cell & Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran Mahdi Alijanianzadeh Department of Cell & Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran Hoda Keshmiri Neghab Department of Medical Laser, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran Mohammad Hasan Soheilifar Department of Medical Laser, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran 2024 08 12 2025 05 03 The skin is a vital organ that plays a crucial role in healing disruptions and abnormalities. Cutaneous wound healing faces some obstacles in certain abnormalities, including in diabetic patients. Various therapeutic approaches have been explored to enhance healing and restore skin integrity. In recent years, exosomes have been introduced as a new cell-free therapy for wound healing. They are defined as naturally secreted nanovesicles released from most cell types into the extracellular space that can impact many targeted cells. In contrast to previous methods, exosomes have a longer half-life in target tissue and exert a more lasting effect. They also have fewer side effects thanks to their natural biological source. Exosomes derived from mesenchymal stem cells (MSCs) have been widely studied for their therapeutic potential, but those from other cell types, such as fibroblasts, remain less explored. This review aims to comprehensively evaluate existing research on the wound-healing effects of fibroblast-derived exosomes (FB-EXOs), highlighting their potential as a novel treatment strategy. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/2299 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/2299/1090