Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 20 1 2026 02 09 122 126 Rahmat Cahyanur Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia Dimas Priantono Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia Andree Kurniawan Department of Internal Medicine, Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Banten, Indonesia Fakhri Rahman Department of Urology, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia Monik Miranda Department of Anatomical Pathology Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo General Hospital Nur Rahadiani Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo General Hospital Endang Izza Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia 2024 11 02 2025 11 18 Supradiaphragmatic lymphadenopathy is a rare finding in prostate cancer. The occurrence of multiple lymphadenopathies forming a conglomerate that resembles lymphoma is also rarely encountered in prostate cancer diagnosis. We present the case of a 71-year-old man who has experienced bilateral leg swelling in the last four months. Multiple lymphadenopathies were detected in the intra-abdominal and supradiaphragmatic regions, along with several metastatic bone lesions. Histopathological and immunohistochemical evaluations confirmed a diagnosis of prostate adenocarcinoma, not otherwise specified (NOS), with a Gleason score of 4+3=7, classified as grade group III, indicating high-volume metastatic prostate cancer. The patient was treated with docetaxel and anti-androgen therapy. His condition was improved after eight cycles of chemotherapy, and his prostate-specific antigen (PSA) levels returned to normal. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/2334 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/2334/1125