Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 20 1 2026 02 09 110 116 EN Sohrab Aghabeigi Hematologic Malignancies Research Center, Research Institute for Oncology, Hematology and Cell Therapy, Tehran University of Medical Sciences, Tehran, Iran Nooshin Ahmadvand Shahid Dr. Beheshti Clinical Research Development Unit, Shahid Dr. Beheshti-Anzali Educational and Medical Hospital, Guilan University of Medical Sciences, Rasht, Iran Seyedeh Mohadese Mosavi Mirkalaie Student Research Committee, School of Medicine, Anzali International Campus, Guilan University of Medical Sciences, Rasht, Iran Azadeh Sedighi Moghadam Razi Pathobiology Lab, Rasht, Iran Arefeh Aref-Eshghi Shahid Dr. Beheshti Clinical Research Development Unit, Shahid Dr. Beheshti-Anzali Educational and Medical Hospital, Guilan University of Medical Sciences, Rasht, Iran 2025 11 28 2026 01 04 This case report describes the presentation for a 65-year-old patient with Sweet's syndrome (SS) presenting with systemic symptoms of general weakness, fever, and painful skin lesions on the right arm. He reported a history of weight loss with night sweats, while skin lesions manifested as erythematous plaques and painful papules. The diagnosis was confirmed by skin biopsy, which showed features of significant neutrophilic infiltrations on histopathology. Further investigations led to the diagnosis of AML associated with Sweet's syndrome. The study highlights the importance of prompt diagnosis of Sweet's syndrome as a paraneoplastic sign and using multi-disciplinary approach for diagnosis and management of patients with skin lesions and cytopenias.   https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/2600 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/2600/1123