Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 4 4 2010 12 15 32 35 Narges Mirjalili Department of Oral Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Mohammah-Hassan Akhavan Karbassi Department of Oral Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Ali-Akbar Davoudi Department of Oral Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 2015 10 01 Introduction: Multiple myeloma is a neoplasm of monoclonal plasmacells which may cause oral manifestations. We report a 50-year-old man with a mass burned out of a post extraction socket. He had recived an eight month period of chemotherapy and was supposed to be ready for hematopoetic stem cell transplantation. After clinical and histopathological examinations, the mass was diagnosed as a plasmacytoid cell proliferation. As the oral manifestations are an indicator of poorly controlled disease, the patient was refered to change his chemotherapeutic regimen. Conclusion: It seems that a team work, including oral medicine specialists may be a valuable opportunity in monitoring and promoting the quality of therapy. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/263 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/263/256