Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 5 1 2011 03 15 34 38 Mehrdad Payandeh Hematology-oncology department, Taleghany Hospital, Kermanshah University of medical science (KUMS), Kermanshah, Iran Mehrnoush Aeinfar Hematology-oncology department, Taleghany Hospital, Kermanshah University of medical science (KUMS),Kermanshah, Iran Mohammad Erfan Zare Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran Hooshang Yusefi Blood Transfusion Center, Kermanshah, Iran Ebrahim Soltanian Blood Transfusion Center, Kermanshah, Iran 2015 10 01 The case of a 52 old women with Hodgkin’s disease of 15 years duration is described. During 4 months ago when she be in the remission phase during every 6 months her follow up she complaint with paranoid minds, urinary incontinency, headache, dizziness and blurred vision started. Papilledema and left hemiparesia were detected. Brain MRI pointed to intracranial invasion by the disease. Therapeutic test with steroids brought to amelioration; therefore, subsequent skull irradiation and chemotherapy were given which improved her condition markedly. For the diagnosis we need newer diagnostic procedures that enable for correct diagnosis of intracranial involvement in Hodgkin’s disease. In doubtful cases, therapeutic test with steroids, followed by chemotherapy and skull irradiation, are indicated, and surgery should be advised only if these measures fail. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/270 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/270/263