Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 5 3 2011 09 15 21 23 Mozaffar Aznab Imam Reza Hospital and Taleghani Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran Bahram Samadzadeh Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran Assad Moradi Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran Abdol Rosol Bardideh Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran Jamal Hoseini Clinical Research Developemental Center, Kermanshah University of Medical Sciences, Kermanshah, Iran Kazhal Kaviani Moghadam Statistic Department, Private Statistic Institute, Kermanshah, Iran 2015 10 01 Introduction: Prostate cancer is one of the most common cancers among males and the second factor resulting to death due to cancer among them.(1) The median age of its diagnosis is 65 years. The initial treatment includes androgen ablation or orchiectomy.(2, 3) In case of patient’s hormone refractory, chemotherapy would be substituted. The objective of this study is the consideration of intermittent chemotherapy’s role in patients’ survival and their quality of life. Materials & Methods: Since (1384,07,07), 25 patients with Hormone Refractory Prostate Cancer that referred to Taleghani & Imam Reza hospital were enrolled in this study, and Taxotere, Mitoxantrone and Navalbine were prescribed along with Estramustin 140 mg/m2 and Prednisolone 10 mg/BD for 4 days respectively(4, 5, 6) and the quality of life (QoL), toxicity and overall survival were evaluated. The most toxicity included grade 2 and 3 neuropathy and neutropenia that was compliant for patients. The overall survival was 22months. Conclusion: Intermittent chemotherapy in elderly patients with hormone refractory prostate cancer provides compliant toxicity and improvement of QoL and overall survival. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/283 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/283/276