Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 5 3 2011 09 15 32 35 Reza Yarani Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran. Kamran Mansouri Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran Azadeh Mahnam Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran 2015 10 01 Angiogenesis which is the recruitment of new blood vessels is a critical Process in several chronic diseases and is an essential component of tumor or cancer progression. Development of therapies aimed at inhibiting the angiogenesis, in combination with classical anti-cancer therapies, is among the most intensively studied approaches to treat the cancer. In this study the effect of chlordiazepoxide (which is a proper anxiolytic drug) on angiogenesis in microcarrier-based collagen gel was assayed. Chlordiazepoxide beside its anxiolytic effect in patients showed strong inhibitory effect on human umbilical vein endothelial cells (HUVECs) tubulogenesis (angiogenesis) in collagen matrix, without toxic effects in the studied doses. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/285 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/285/278