Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 5 4 2011 12 15 30 33 Shahsanam Gheibi Gastroentrology Department, Urmia University of Medical Sciences,Urmia, Iran Rahim Mahmudloo Thoracic surgery Department, Urmia University of Medical Sciences,Urmia, Iran Ali Eishi-Oskuie Hematology- Medical Oncology Department, Emam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran Nasim Valizadeh Hematology- Medical Oncology Department, Emam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran 2015 10 01 Gastrointestinal stromal tumors (GISTs) are uncommon tumors of the gastrointestinal (GI) tract that occur predominantly in adults. These tumors originated from Cajal cells have positive mutations for KIT (CD117) or platelet-derived growth factor receptor (PDGFRA). GIST especially multiple GISTs are very rare in children and lacking mutations in KIT. We present a previously healthy 13 year- old girl with history of hematemesis and melena for two months which has caused severe anemia requiring ICU admission with final diagnosis of KIT positive multiple GISTs in stomach. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/295 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/295/288