Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 6 2 2012 06 15 29 31 Vinaykumar Bohara Institute Of Hematology and Transfusion Medicine, Kolkata, India. Lalit Raut Institute Of Hematology and Transfusion Medicine, Kolkata, India. Siddhartha Ray Institute Of Hematology and Transfusion Medicine, Kolkata, India. Utpal Chaudhuri Institute Of Hematology and Transfusion Medicine, Kolkata, India. 2015 10 01 The most frequently studied association between a hepatitis virus and Non Hodgkin lymphoma (NHL) has been with hepatitis C virus (HCV). Association with Hepatitis B virus (HBV) is less studied. In this regard mixed cryoglobulinemia (MC) is more commonly associated with HCV than HBV. Still rarer is cryofibrinogenemia in these patients.  Lack of symptoms in addition its rarity delays the diagnosis of cryofibrinogenemia and thus the underlying disorders like lymphoma, etc. This case report describes the diagnosis of unsuspected B cell lymphoma in a patient who presented with absolutely no hematological signs and symptoms and underscores the importance of integrated multidisciplinary approach in the diagnosis of such rare presentations of common hematological malignancies. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/333 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/333/319