Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 6 4 2015 10 13 14 19 EN Mozhdeh Dabirian Assistant Professor of cardiology & fellowship in Echocardiography, Department of Cardiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Rozita Jalalian Assistant Professor of cardiology & fellowship in Echocardiography, Department of Cardiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Hossein Karami Associate Professor of Pediatric Oncology, Department of Pediatric oncology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Mehrnoosh Kowsarian Professor of pediatric endocrinology, Thalassemia Research Center, Bouali Sina Hospital, Mazandaran University of Medical sciences, Sari, Iran. Abes Ahmadi Resident of Pediatrics, department of Pediatrics, Bouali Sina Hospital, Mazandaran University of Medical sciences, Sari, Iran. Leila Shokohi GP, research Fellow, Research and Technology Department of Mazandaran Medical Science and Health Services, Sari, Iran. Reza Alizadeh Navaei M-Phill course of Ph.D by Research, Molecular and cellular biology research Center, Mazandaran University of Medical Sciences, Sari, Iran. 2015 10 13 2015 10 13 Background and Aim: Iron overload in patients with thalassemia major is one of the most important complications of this disease and its cardiac complications are the most important causes of death in these patients.MRI T2 is the perfect device to assess the amount of iron deposited in the heart of thalassemia patients, but it causes waste of time and also is an expensive diagnostic method. Tissue Doppler echocardiography is the newer method for this evaluation.Herein, this study was conducted to determine efficacy and specificity of tissue Doppler echocardiography in the assessment of heart iron overload in patients with thalassemia major. Materials & Methods: It was a diagnostic power assessment research?? performed on 50 patients with thalassemia major aged ≥ 15 years old that had been visited in BoualiSina Hospital in sari, Iran. After the study was explained and patients agreed to participate, written informed consent was obtained. All the patients underwent MRI T2* and tissue Doppler echocardiography results were obtained. The collected data were processed with SPSS 16 and specificity and efficacy of tissue Doppler echocardiography were obtained. In all analysis, P value< 0.05 was considered statistically significant. Result: Patients were divided into four groups: normal amount of iron in the heart tissue, mild, moderate and severe. There was a good compatibility between results of MRI T2* and tissue Doppler echocardiography. Conclusion: we can offer that tissue Doppler echocardiography is a worthy method for evaluating cardiac complications of iron overload in patients with thalassemia major. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/356 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/356/324