Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 9 3 2015 09 15 The Newly Identified T Helper 22 Cells Lodge in Leukemia 143 154 Gholamreza Azizi Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran. AND Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Mohsen Rastegar Pouyani Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Shadi Sadat Navabi Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Reza Yazdani Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. AND Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Fatemeh Kiaee Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Abbas Mirshafiey Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 14 Leukemia is a hematological tumor in which the malignant myeloid or lymphoid subsets play a pivotal role. Newly identified T helper cell 22 (Th22) is a subset of CD4(+) T cells with distinguished gene expression, function and specific properties apart from other known CD4(+) T cell subsets.Th22 cells are characterized by production of a distinct profile of effector cytokines, including interleukin (IL)-22, IL-13, and tumor necrosis factor-α (TNF-α). The levels of Th22 and cytokine IL-22 are increased and positively related to inflammatory and autoimmune disorders. Recently, several studies have reported the changes in frequency and function of Th22 in acute leukemic disorders as AML and ALL. This review discusses the role of Th22 and its cytokine IL-22 in the immunopathogenesis of leukemic disease. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/380 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/380/418