Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 8 4 2014 12 15 45 48 Farzaneh Ashrafi Hematology &Oncology section, Department of Internal Medicine, School of Medicine, Isfahan University of Medical sciences, Isfahan, Iran. Farid Kowsari Department of Pathology, School of Medicine, Tehran University of Medical sciences, Tehran, Iran. Ali Derakhshandeh Department of Internal Medicine, School of Medicine, Isfahan University of Medical sciences, Isfahan, Iran. Peyman Adibi Gastroenterology section, Department of Internal Medicine, School of Medicine, Isfahan University of Medical sciences, Isfahan, Iran. 2015 10 14 A 45-year-old female patient with a diagnosis of ulcerative colitis complicated with composite lymphoma in the spleen and para-aortic lymph node presented with a one-month history of malaise, weakness and fatigue. Only mesalamine kept ulcerative colitis under control. In physical examination, splenomegaly was revealed and pancytopenia was obtained from laboratory data. Computed tomography scan revealed para-aortic mediastinal lymphadenopathy with splenomegaly. Splenectomy and excisional biopsy of abdominal lymph node were performed and disease was diagnosed as composite lymphoma, consisting of diffuse large B-cell lymphoma and nodular sclerosing Hodgkin lymphoma. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/404 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/404/393