Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 8 1 2014 03 15 46 50 Mohsen Vakili Sadeghi Medical oncologist, assistant professor of Babol University of medical sciences, Babol, Iran. Majid Sharbatdaran Pathologist, assistant professor of Babol University of medical sciences, Babol, Iran. Askari Noorbaran General Surgeon, assistant professor of Babol University of medical sciences, Babol, Iran. Sepideh Siadati Pathologist, assistant professor of Babol University of medical sciences, Babol, Iran. Daryoush Moslemi Radiation oncologist, assistant professor of Babol University of medical sciences, Babol, Iran. Shahriar Shafahi Pathologist, assistant professor of Babol University of medical sciences, Babol, Iran. 2015 10 14 Colorectal cancer most commonly metastasizes to the liver and lung. Metastatic colon carcinoma (MCC) to the breast is extremely rare. Krukenberg tumor is an uncommon metastatic tumor of the ovary. Case presentation: A 38 years woman presented with abdominal pain. In evaluation colon cancer was diagnosed at stage 3. FOLFOX chemotherapy was done. After one year she developed Krukenberg tumor. Few days after ovarian tumor resection breast tumor was diagnosed. In immunohistochemistry both ovarian and breast tumors was CK7 negative, CK20 positive, compatible with colon cancer origin. This is the first case of simultaneous metastasis of colon cancer to two rare sites. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/428 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/428/369