Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 8 1 2014 03 15 41 5 Aida Iranpour Department of Oncology and Rheumatology, Rasool Akram Hospital, Tehran, Iran. Reihaneh Mahmoodian Department of Oncology and Rheumatology, Rasool Akram Hospital, Tehran, Iran. Anoosheh Haghighi Department of Oncology and Rheumatology, Rasool Akram Hospital, Tehran, Iran. Masoud Vakili Department of Oncology and Rheumatology, Rasool Akram Hospital, Tehran, Iran. Ali Shahriari-Ahmadi Department of Oncology and Rheumatology, Rasool Akram Hospital, Tehran, Iran. Shokoufeh Hajsadeghi Department of Oncology and Rheumatology, Rasool Akram Hospital, Tehran, Iran. Mohsen Arabi Department of Oncology and Rheumatology, Rasool Akram Hospital, Tehran, Iran. 2015 10 14 Secondary systemic vasculitis and nonbacterial endocarditis are rare events. We report a case presented with different manifestations of underlying malignancy such as systemic vasculitis, non bacterial endocarditis and DIC (disseminated intravascular coagulopathy). Efforts to find the source of malignancy was unsuccessful and due to patient's unwillingness for further evaluation, finally under the diagnosis of metastatic disease of unknown primary, patient is receiving cyclic chemotherapy. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/429 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/429/368