Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 11 3 2016 07 11 247 250 EN Farzaneh Ashrafi Hematologist and Medical oncologist, Isfahan University of Medical sciences, Isfahan, Iran Bijan Iraj Endocrinologist, Isfahan University of Medical sciences, Isfahan, Iran Pardis Nematollahi Pathologist, Isfahan University of Medical sciences, Isfahan, Iran Ali Darakhshandeh Internist, Isfahan University of Medical sciences, Isfahan, Iran 2016 03 04 2016 06 08 Hypercalcemia is a common finding in patients with multiple myeloma. Clinical manifestations of hypercalcemia correlate with the level of serum calcium. Ionized serum calcium (Ca (I)) will be increased in true hypercalcemia. In pseudohypercalcemia the Ionized Ca is normal, although binding of calcium to abnormal immunoglobulin causes increased serum calcium level. In the asymptomatic multiple myeloma patients with moderate to severe hypercalcemia, measurement of ionized calcium is critical to exclude pseudohypercalcemia. Here, we describe an asymptomatic 44-year-old man with multiple myeloma who had severe hypercalcemia, but normal serum Ionized Ca level.  https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/576 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/576/565