Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 12 3 2018 07 04 165 167 EN Irappa Madabhavi Department of Medical and Paediatric Oncology, Kerudi Cancer Hospital, Bagalkot, Karnataka, India Apurva Patel Department of Medical and Paediatric Oncology, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India Mitul Modi Department of Pathology, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India Swaroop Revannasiddaiah Department of Radiotherapy, Government Medical College, Haldwani, India Chidanand Chavan Department of Medical and Paediatric Oncology, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India 2016 07 21 2016 07 28 Chloroma (granulocytic sarcoma or myeloid sarcoma) is a rare malignant extra-medullary neoplasm of myeloid precursor cells. It is usually associated with myeloproliferative disorders but very rarely may precede the onset of leukaemia. Here we are presenting a rare case of chloroma in  a female patient without initial presentation of AML. 38 year old female patient, with performance score-1 had complaining of per vaginal bleeding for 1-2 days. Patient consulted gynaecologist and underwent biopsy from anterior fornix of vagina. Biopsy material was positive for LCA (leukocyte common antigen), MPO (myeloperoxidase), c-kit positive on IHC (immunohistocytochemistry) while negative for cytokeratin, synaptophysin, chromogranin, CD20 (cluster of differentiation. Whole body CT scan was non informative except mass lesion at vagina. Patient was given 3+7 induction chemotherapy which was tolerated well followed by high dose cytarabine as consolidation therapy. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/653 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/653/635