Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 12 1 2018 01 05 1 3 EN Guido Lancman Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA Amir Steinberg Tisch Cancer Institute, Mount Sinai Hospital, New York, NY, USA Janice Gabrilove Tisch Cancer Institute, Mount Sinai Hospital, New York, NY, USA 2016 11 18 2018 01 02 Serpentine supravenous hyperpigmentation (SSH) is a rare vasculo-cutaneous entity that has been associated with peripheral infusion of chemotherapy agents, in particular 5-FU1-3,but also seen with docetaxel4,5, fotemustine6, and vinorelbine7. It consists of a marked hyperpigmentation along the superficial network of veins proximal to the chemotherapy infusion site and was originally described in a 1976 case report in association with 5-FU1. Here, for the first time, we report SSH in association with R-CHOP chemotherapy  https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/700 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/700/588