Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 12 4 2018 10 03 Tafro Syndrome: A Case Report from Turkey and Review of the Literature 252 258 EN Zeki İslamoğlu Department of Gastroenterology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey Ali Duman Department of Gastroenterology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey Göktuğ Şirin Department of Gastroenterology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey Hasan Yılmaz Department of Gastroenterology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey Meral Mengüç Department of Hematology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey Yiğit Erçetin Department of Pathology, Faculty of Medicine, Marmara University, İstanbul, Turkey Süheyla Bozkurt Department of Pathology, Faculty of Medicine, Marmara University, İstanbul, Turkey Sadettin Hülagü Department of Gastroenterology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey Altay Çelebi Department of Gastroenterology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey 2018 03 25 2018 07 29 TAFRO syndrome is a rare subtype of the Castleman’s disease which has been described over the last years. The name of TAFRO syndrome comes from thrombocytopenia, anasarca, myelofibrosis, renal dysfunction, and organomegaly. We report a young Turkish male patient presented with fever, night sweats, fatigue, nausea, bilateral pretibial pitting edema, abdominal pain and watery diarrhea. PET/CT revealed multiple lymphadenopathies in cervical, axillary, mediastinal, paraaortic, mesenteric and inguinal lymph nodes. Excisional lymph node biopsy showed atretic germinal centers and expanded interfollicular areas, containing sheets of plasma cells. The R-CHOP regimen was started, and his signs and symptoms improved after the treatment. The current case confirms the unique presentation of this syndrome, helping to understand its clinical course and treatment strategy. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/930 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/930/738