Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 6 2 2012 06 15 1 7 Rashmi Koul Associate Prof, University of Saskatchewan, Staff Radiation Oncologist, Allan Blair Cancer Centre 4101 Monica Behl Associate Prof, University of Saskatchewan, Staff Radiation Oncologist, Allan Blair Cancer Centre 41 Joshua Giambattista Second year Medical student, University of Saskatchewan, Canada Theresa Bradel Provincial Leader Radiation therapy, Saskatchewan Cancer Agency, Canada Renne Belitski Clinical associate, Department of Radiation Oncology, Allan Blair Cancer Centre, 4101 Dewdney Ave, R Arbind Dubey Astt Prof, University of Saskatchewan, Staff Radiation Oncologist, Allan Blair Cancer Centre, 4101 2015 10 01 Purpose: Nowadays cancer patients want more detailed information and greater participation in decisions about their care. As a consequence, the demands on health care system to satisfy the complex care needs of oncology patients have increased tremendously. Methods and Materials: As part of a quality improvement exercise at the Radiation Oncology department, Allan Blair Cancer Center, Regina, Saskatchewan, Canada, a survey was undertaken to ascertain the level of patient satisfaction with the information and care they were receiving from their care team during their first interaction with physicians till they finish radiation. In addition, the patients’ anxiety levels during radiation were investigated as well. Both questionnaires were given to patients on first day of their radiotherapy and after the completion of their radiotherapy. Results: Total of 122 patients were enrolled in the study and 100 of them both questionnaires pre and post radiation therapy. Majority of  patients were satisfied with information they received regarding their illness (94%) and treatment toxicity (81%), but few less  satisfied with the information they received regarding lifestyle issues such as diet, exercise, time off work, sexuality and smoking. The patients showed a statistically significant reduction in both their State and Trait Anxiety scores following radiotherapy (p<0.001). The results of the two-sample t-test were significantly lower in post radiation period (State trait r = 0.521, Anxiety trait r=0.701). Conclusions: Research has established many barriers for proper communication. The initial meeting should be unhurried and there is a risk that contents may not be grasped so, there should be planned repetitions. Several repetitions and subsequent visits may be needed for a patient to hear what is said, respond to it, and retain this information in their mind. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/327 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/327/313

Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 6 2 2012 06 15 8 12 Taher Entezari-Maleki Department of Clinical Pharmacy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran Safa Margedari Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Kheirollah Gholami Faculty of Pharmacy, and Research Center for Rational Use of Drug, Tehran University of Medical Sciences, Tehran,Iran Molouk Hadjibabaie Faculty of Pharmacy, and Research Center for Rational Use of Drug, Tehran University of Medical Sciences, Tehran, Iran Mohammad Bagher Oghazian Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Jamshid Salamzadeh Department of Clinical Pharmacy, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran Seyed Hamid Khoee Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Ardeshir Ghavamzadeh Hematology-Oncology and SCT Research Center, Department of Hematology-Oncology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran 2015 10 01 Background and Aims: Adverse drug reactions (ADRs) are one of the major leading causes of death in the world. This study was designed and conducted because of the importance of adverse events in the cancer treatment setting and regarding this issue there is no study exploring adverse reactions of acute hematologic malignancy chemotherapy in Iranian population. Methods: This was a prospective, cross-sectional study performed at hematology-oncology and bone marrow transplantation research center. The inclusion criteria were all patients with acute hematologic malignancies such as ALL and AML, which were admitted over an 8 months period and were ≥15 years old age. Each ADR was categorized based on the WHO system organ classification. Results and Conclusion: The total number of detected ADRs was 310 in total of 105 patients. Eight patients (7.6 %) experienced only one ADR, eleven patients (10.5%) experienced two ADRs and eighty-six of them (82%) experienced more than two ADRs. there was a significant relationship between the number of ADRs and type of hematologic malignancy. In this regard, the patients with AML malignancy showed more number of ADRs than with ALL malignancy (p<0.05) The Gastro-intestinal system disorders were the most common affected system-organ by chemotherapy regimens (33.5%). We suggest more well designed studies to determine the relation between the number of ADRs and study factors. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/328 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/328/314

Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 6 2 2012 06 15 13 16 Arash Abdolmaleki Dept. of Biology, Faculty of Science, Mohaghegh Ardebily University, Ardebil, Iran F Sanginabadi Social Security, Faculty of Medicine, Kurdestan University of Medical Sciences, Kurdestan, Iran A Rajabi Dept. of Physical Education, University of Mohaghegh Ardabili, Ardebil, Iran R Saberi Faculty of Medicine, Kurdestan University of Medical Sciences, Kurdestan, Iran 2015 10 01 Background: Now a days researchers have shown grean interest in electromagnetic waves which spread from devices such az microwaves,satellites,tv,cell phones etc,due to various reports of their devasting effects on animal growth and health.in this study the effects of these radiations on blood cells is investigated. Methods: In the present study the effect of radiation on blood parameters in the factory workers, including welders, computer operators, individuals working in the furnace and the control group were investigated. In order to determine changes in blood parameters, blood samples were taken from the workers and then were analyzed by standard procedures and compared with control group of changes in blood parameters. Spss soft ware for data analysis and one-way ANOVA and Duncan test was used. Results: Results have shown that individuals affected by these waves show significant increase in the amount of RBC, MCV and platelet (P <0.05). While the amount of hemoglobin, the percentage of lymphocytes and WBC was reduced. Conclusion: These effects could be due to the stimulatory effects of radiation on cell division in bone marrow cells is But the effects of radiation on living systems requires further research. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/329 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/329/315

Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 6 2 2012 06 15 17 21 Mehrdad Payandeh Medical Biology Research Center, Kermanshah University of Medical Science, Kermanshah, Iran. Hoshang Yousefi Blood Transfusion Research Center, High Institue for Research and Education in Transfusion Medicine,Science, Kermanshah, Iran. Mohammad Erfan Zare Medical Biology Research Center, Kermanshah University of Medical Science, Kermanshah, Iran Atefeh Nasir Kansestani Medical Biology Research Center, Kermanshah University of Medical Science, Kermanshah, Iran; Zohreh Rahimi Medical Biology Research Center, Kermanshah University of Medical Science, Kermanshah, Iran Darioush Pourmand Department of Medical Lab Science, Paramedicine Faculty, Kermanshah University of Medical Science, Kermanshah, Iran Amir Hossein Hashemian Department of Biostatistics, Faculty of Public Health, Kermanshah University of Medical Science, Kermanshah, Iran Mahmood Aeinfar Student Research Committee, Electronic Department, Faculty of Technology, Islamic Azad University,Kermanshah, Iran Mehrnoush Aeinfar Medical Biology Research Center, Kermanshah University of Medical Science, Kermanshah, Iran. Farhad Shaveisi Zadeh Departments of Medical Genetics, Faculty of Medicine, Sahid Beheshti University of Medical Science, Kermanshah, Iran 2015 10 01 Introduction: The main inhibitors of coagulation pathway are antithrombin (AT), protein C and protein S. These inhibitors are necessary to prevent thromboembolism. Hereditary deficiency of inhibitors is the main cause of alteration in balance between the anti-clotting and the formation of thrombin. Patients with this abnormality are susceptible to venous thromboembolism (VTE). Two major clinical manifestation of VTE are deep vein thrombosis (DVT) and pulmonary embolism (PE). The aim of present study was to investigate the frequency of coagulation inhibitor proteins and resistance to activated protein C (APC-R) in DVT patients from Kermanshah province of Iran with Kurdish ethic background. Materials and methods: We investigated all patients with thrombophilia who referred to Iranian Blood Transfusion Organization from May 2011 to March 2012. The levels of protein C, protein S and antithrombin were measured using STAGO kits, France (Diagnostica Stago) and the APC-R level was detected using Pefakit® kit. Results: After excluding patients with confounding factors, 54 patients were remained. Our results showed that acquired risk factors are the most common causes of DVT in the present study. In our study protein C deficiency was found to be the most hereditary risk factor followed in frequency by APC-R. Also, in 16 patients (29.6%) there were combined hereditary risk factors with deficiency in 2 or 3 factors. Conclusion: Our results showed protein C deficiency was the prevalent cause of DVT in our patients. Also, different pattern of hereditary risk factors in our patients compared to other regions of Iran could be attributed to different ethnic background of our patients. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/330 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/330/316

Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 6 2 2012 06 15 22 26 Majid Mossahebimohammadi Department of Hematology and Blood banking, Tarbiat Modares University, Tehran, Iran Saeid Kaviani Department of Hematology and Blood banking, Tarbiat Modares University, Tehran, Iran Mina Soufizomorrod Department of Hematology and Blood banking, Tarbiat Modares University, Tehran, Iran Masoud Soleimani Department of Hematology and Blood banking, Tarbiat Modares University, Tehran, Iran Saeid Abroun Department of Hematology and Blood banking, Tarbiat Modares University, Tehran, Iran Gholamreza Khamisipour Department of Allied Medicine, Bushehr University of medical sciences, Bushehr, Iran Najmaldin Saki Research Center of Thalassemia & Hemoglobinopathy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran 2015 10 01 Embryonic stem cells (ESCs) as pluripotent stem cells have the potential to give rise to all three germ layer cells. Also, these cells have the self-renewing ability. ESCs could differentiate into most of cell lineages. Lymphocytes generated from hematopoietic stem cells. We designed a feeder free culture condition to generate lymphoid lineage cells from ESCs. We demonstrated that IL-7 plays critical role in differentiation of ESCs into lymphoid lineage and expression of specific cell markers such as CD3, CD19 and CD25 after 14 days of differentiation by RT-PCR. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/331 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/331/317

Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 6 2 2012 06 15 27 28 Majid Farshdousti Hagh Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Najmaldin Saki Thalassemia and Hemoglobinopathy Research Center, Jundishapur University of Medical Sciences, Ahvaz, Iran Gholamreza Khamisipour Bushehr University of Medical Sciences, Bushehr, Iran 2015 10 01 No Abstract https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/332 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/332/318

Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 6 2 2012 06 15 29 31 Vinaykumar Bohara Institute Of Hematology and Transfusion Medicine, Kolkata, India. Lalit Raut Institute Of Hematology and Transfusion Medicine, Kolkata, India. Siddhartha Ray Institute Of Hematology and Transfusion Medicine, Kolkata, India. Utpal Chaudhuri Institute Of Hematology and Transfusion Medicine, Kolkata, India. 2015 10 01 The most frequently studied association between a hepatitis virus and Non Hodgkin lymphoma (NHL) has been with hepatitis C virus (HCV). Association with Hepatitis B virus (HBV) is less studied. In this regard mixed cryoglobulinemia (MC) is more commonly associated with HCV than HBV. Still rarer is cryofibrinogenemia in these patients.  Lack of symptoms in addition its rarity delays the diagnosis of cryofibrinogenemia and thus the underlying disorders like lymphoma, etc. This case report describes the diagnosis of unsuspected B cell lymphoma in a patient who presented with absolutely no hematological signs and symptoms and underscores the importance of integrated multidisciplinary approach in the diagnosis of such rare presentations of common hematological malignancies. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/333 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/333/319

Tehran University of Medical Sciences International Journal of Hematology-Oncology and Stem Cell Research 2008-2207 6 2 2012 06 15 32 34 Nasim Valizadeh Department of Hematology/Medical Oncology, Urmia University of Medical Sciences, Urmia, Iran Rahim Nejad Rahim Department of Infectious Disease, Urmia University of Medical Sciences, Urmia, Iran Shahin Nateghi Medical Student, Departmen of Medicine, Urmia University of Medical Sciences, Urmia, Iran 2015 10 01 Patients with lymphoproliferative disorders have cellular immune deficiency and are susceptible to typical and atypical mycobacterial infections.Hairy cell leukemia is a B-cell type lymphoproliferative disorder.2-CDA is the choice of treatment for patients with hairy cell leukemia. It is a synthetic antineoplastic agent with immunosuppressive effects.We present development of pulmonary and meningeal TB in a case of hairy cell leukemia 8 months after treatment with 2-CDA. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/334 https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/334/320