International Journal of Hematology-Oncology and Stem Cell Research 2017. 11(2):108-113.

Iron Profile and Inflammatory Status of Overweight and Obese Women in Sari, North of Iran
Ramin Shekarriz, Mohammad Mehdi Vaziri

Abstract


Background: It has been suggested that inflammatory state due to obesity can lead to alteration in iron metabolism. Women in reproductive age are at higher risk of iron deficiency. In this study, we aimed to evaluate inflammatory status and iron markers in young overweight and obese women.

Subjects and Methods: In this study, 120 young and healthy women with a BMI ≥ 25 kg/m2 were enrolled. Biochemical data including iron profile and inflammatory markers were analyzed using mean ± standard deviation or median (interquartile range) and multivariate multiple regression model via MANOVA.

Results: Iron deficiency anemia (hemoglobin < 120 g/l) and iron deficiency without anemia (serum ferritin<30.0 mg/l) were detected in 21.67% and 33.33% of participants, respectively. Multivariate modeling showed that BMI was a significant predictor of transferrin saturation (p = 0.037), CRP (p = 0.013), soluble transferrin receptor (p=0.045), and soluble transferrin receptor/ ferritin ratio (0.015).

Conclusion: The results of this study supported the positive association between obesity and inflammation and mild changes in iron markers.

 


Keywords


Iron deficiency; Obesity; Iron profile; Inflammatory status

Full Text:

PDF

References


McClung JP, Karl JP. Iron deficiency and obesity: the contribution of inflammation and diminished iron absorption. Nutr Rev. 2009; 67(2): 100–4.

Cheng HL, Bryant CE, Rooney KB, et al. Iron, hepcidin and inflammatory status of young healthy overweight and obese women in Australia. PloS One. 2013; 8(7): e68675.

Neymotin F, Sen U. Iron and obesity in females in the United States. Obesity. 2011; 19(1): 191–9.

Del Giudice EM, Santoro N, Amato A, et al. Hepcidin in obese children as a potential mediator of the association between obesity and iron deficiency. J Clin Endocrinol Metab. 2009; 94(12): 5102–7.

Wenzel BJ, Stults HB, Mayer J. Hypoferraemia in obese adolescents. Lancet. 1962; 2(7251): 327–8.

Ganz T, Nemeth E. Hepcidin and iron homeostasis. Biochim Biophys Acta. 2012; 1823(9): 1434–43.

Aktas G, Alcelik A, Yalcin A, et al. Treatment of iron deficiency anemia induces weight loss and improves metabolic parameters. Clin Ter. 2014; 165(2): e87–9.

Medeiros DM, Stoecker B, Plattner A, et al. Iron deficiency negatively affects vertebrae and femurs of rats independently of energy intake and body weight. J Nutr. 2004; 134(11): 3061–7.

Bekri S, Gual P, Anty R, et al. Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH. Gastroenterology. 2006; 131(3): 788–96.

Cepeda-Lopez AC, Aeberli I, Zimmermann MB. Does obesity increase risk for iron deficiency? A review of the literature and the potential mechanisms. Int J Vitam Nutr Res. 2010; 80(4-5): 263–70.

Abo Zeid AA, Saka MH El, Abdalfattah AA, et al. Potential factors contributing to poor iron status with obesity. Alex J Med. 2014; 50(1): 45–8.

Lecube A, Carrera A, Losada E, et al. Iron deficiency in obese postmenopausal women. Obesity. 2006; 14(10): 1724–30.

Menzie CM, Yanoff LB, Denkinger BI, et al. Obesity-related hypoferremia is not explained by differences in reported intake of heme and nonheme iron or intake of dietary factors that can affect iron absorption. J Am Diet Assoc. 2008; 108(1): 145–8.

Yanoff L, Menzie C, Denkinger B, et al. Inflammation and iron deficiency in the hypoferremia of obesity. Int J Obes. 2007; 31(9): 1412–9.

Javaheri-Kermani M, Farazmandfar T, Ajami A, et al. Impact of hepcidin antimicrobial peptide on iron overload in tuberculosis patients. Scand J Infect Dis. 2014; 46(10): 693–6.

Fenkci S, Rota S, Sabir N, et al. Relationship of serum interleukin-6 and tumor necrosis factor alpha levels with abdominal fat distribution evaluated by ultrasonography in overweight or obese postmenopausal women. J Investig Med. 2006; 54(8): 455–60.

Smirnova MG, Kiselev SL, Gnuchev NV, et al. Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion. Eur Cytokine Netw. 2002; 13(2): 161–72.

Karl JP, Lieberman HR, Cable SJ, et al. Poor iron status is not associated with overweight or overfat in non-obese pre-menopausal women. J Am Coll Nutr. 2009; 28(1): 37–42.

Tussing-Humphreys LM, Nemeth E, Fantuzzi G, et al. Elevated systemic hepcidin and iron depletion in obese premenopausal females. Obesity. 2010; 18(7): 1449–56.

Guo X, Zhou D, An P, et al. Associations between serum hepcidin, ferritin and Hb concentrations and type 2 diabetes risks in a Han Chinese population. Br J Nutr. 2013; 110(12): 2180–5.

Sedlackova T, Racek J, Rajdl D, et al. Relationship between hepcidin and ferritin in haemodialysed patients. Wien Klin Wochenschr. 2013; 125(15-16): 448–52.

Mecklenburg I, Reznik D, Fasler-Kan E, Drewe J, Beglinger C, Hruz P. Serum hepcidin concentrations correlate with ferritin in patients with inflammatory bowel disease. J Crohns Colitis. 2014; 8(11): 1392–7.


Refbacks

  • There are currently no refbacks.


Creative Commons Attribution-NonCommercial 3.0

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.