Meta-Analysis of Gene Expression Profiles in Acute Promyelocytic Leukemia Reveals Involved Pathways
-
Mahdi Jalili
,
Ali Salehzadeh-Yazdi
,
Saeed Mohammadi
,
Marjan Yaghmaie
,
Ardeshir Ghavamzadeh
,
Kamran Alimoghaddam
Abstract
Background: Acute promyelocytic leukemia (APL) is a unique subtype of acute leukemia. APL is a curable disease; however, drug resistance, early mortality, disease relapse and treatment-related complications remain challenges in APL patient management. One issue underlying these challenges is that the molecular mechanisms of the disease are not sufficiently understood.
Materials and Methods: In this study, we performed a meta-analysis of gene expression profiles derived from microarray experiments and explored the background of disease by functional and pathway analysis.
Results: Our analysis revealed a gene signature with 406 genes that are up or down-regulated in APL. The pathway analysis determined that MAPK pathway and its involved elements such as JUN gene and AP-1 play important roles in APL pathogenesis along with insulin-like growth factor–binding protein-7.
Conclusions: The results of this meta-analysis could be useful for developing more effective therapy strategies and new targets for diagnosis and drugs.
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| Issue | Vol 11, No 1 (2017) | |
| Section | Articles | |
| Keywords | ||
| Acute promyelocytic leukemia Gene expression profile Meta-Analysis Functional analysis | ||
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