First Report of Known Rare RhNull Phenotype Individuals in Iran

  • Ehsan Shahverdi Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
  • Mostafa Moghaddam Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
  • Hassan Abolghasemi Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Keywords: Rhnull, Blood group, Hemolytic anemia, Antibody screening, Iran

Abstract

Rhnull phenotype is a rare blood group with a frequency of approximately 1 in 6 million individuals, transmitted via an autosomal recessive mode. It is characterized by the weak (Rh mod) or lack (Rh null) of expression of all Rh antigens on the red cells. The clinical significance of its assessment is that such patients with Rhnull syndrome are associated with chronic hemolytic anemia of varying degrees. Another clinical importance is that such subjects readily form alloantibodies when exposed to Rh antigens. We report herein a rare Rhnull phenotype in a sibling which was detected as a part of the difficult sample work-up for red cell antibody screening and identification. 

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Published
2018-07-04
How to Cite
1.
Shahverdi E, Moghaddam M, Abolghasemi H. First Report of Known Rare RhNull Phenotype Individuals in Iran. ijhoscr. 12(3):180-3.
Section
Case Report(s)