Treatment of Acute Lymphoid Leukemia Refractory to Classic First-Line and Rescue Protocols

  • Flávia Tobaldini Russo 1) Instituto Brasileiro de Controle do Câncer (IBCC), São Paulo, Brazil 2) Bio Sana`s serviços Médicos, São Paulo, Brazil
  • Maria Cristina Martins de Almeida Macedo 1) Instituto Brasileiro de Controle do Câncer (IBCC), São Paulo, Brazil 2) Bio Sana`s serviços Médicos, São Paulo, Brazil
  • Pedro Amoedo Fernandes 1) Instituto Brasileiro de Controle do Câncer (IBCC), São Paulo, Brazil 2) Bio Sana`s serviços Médicos, São Paulo, Brazil
  • Larissa Yukari Okada 1) Instituto Brasileiro de Controle do Câncer (IBCC), São Paulo, Brazil 2) Bio Sana`s serviços Médicos, São Paulo, Brazil
  • Lucas Augusto Monetta da Silva Faculdade de Ciências Médicas Santa Casa de São Paulo, São Paulo, Brazil
  • Camila Menin Simões 1) Instituto Brasileiro de Controle do Câncer (IBCC), São Paulo, Brazil 2) Bio Sana`s serviços Médicos, São Paulo, Brazil
  • Jamilla Neves Cavalcante 1) Instituto Brasileiro de Controle do Câncer (IBCC), São Paulo, Brazil 2) Bio Sana`s serviços Médicos, São Paulo, Brazil
  • Aline de Almeida Simões 1) Instituto Brasileiro de Controle do Câncer (IBCC), São Paulo, Brazil 2) Bio Sana`s serviços Médicos, São Paulo, Brazil
  • Manuella de Souza Sampaio Almeida 1) Instituto Brasileiro de Controle do Câncer (IBCC), São Paulo, Brazil 2) Bio Sana`s serviços Médicos, São Paulo, Brazil
  • Maricy Almeida Viol Ferreira Lopes 1) Instituto Brasileiro de Controle do Câncer (IBCC), São Paulo, Brazil 2) Bio Sana`s serviços Médicos, São Paulo, Brazil
  • Roberto Luiz da Silva Mail 1) Instituto Brasileiro de Controle do Câncer (IBCC), São Paulo, Brazil 2) Bio Sana`s serviços Médicos, São Paulo, Brazil
Keywords:
Acute Lymphoblastic Leukemia; Lymphoid cells; Relapsed leukemia

Abstract

Acute Lymphoblastic Leukemia is a very aggressive malignant disorder of lymphoid cells in adults, with recurrence (30 to 60% of the cases) after the initial treatment. Until this moment, there is no gold standard therapy for the treatment of adult patients with acute relapsed/refractory lymphoblastic leukemia. In this case report, we describe two cases of relapsed leukemia: one of lymphocytic leukemia B and one of trilineage leukemia, which presented a satisfactory response to treatment with Bortezomib associated with Vincristine, Dexamethasone, and Bendamustine.

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Published
2020-04-07
How to Cite
1.
Russo F, Macedo MC, Fernandes P, Okada L, da Silva L, Simões C, Cavalcante J, Simões A, Almeida M, Lopes M, da Silva R. Treatment of Acute Lymphoid Leukemia Refractory to Classic First-Line and Rescue Protocols. Int J Hematol Oncol Stem Cell Res. 14(2):123-126.
Section
Case Report(s)