Blood Parameters in Treatment with Arsenic Trioxide in Acute Promyelocytic Leukemia: A Systematic Review

  • Mehdi Mohammadi Kanesbi Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Lida Jarahi Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mohammad Reza Keramati Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Keywords:
Acute promyelocytic leukemia; Arsenic trioxide; All-trans retinoic acid; Chemotherapy; Disseminated intravascular coagulation

Abstract

Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML). APL is famed with some special blood coagulation disorders such as disseminated intravascular coagulation (DIC). The therapeutic methods of APL contain All Trans Retinoic Acid (ATRA), arsenic trioxide (ATO) or/and chemotherapy. Many studies have been done on APL blood disorders and its treatment. These studies have shown different results. In this systematic article, we tried to review the effect of ATO therapy with or without ATRA and chemotherapy on DIC parameters (D.dimer, Prothrombin Time, Activated Partial Thrombin Time, Platelet count) in APL patients. The result of included studies demonstrated that although ATO can reduce the number of malignant cells in the bone marrow and peripheral blood, it does not have enough potential to attenuate the danger of high score DIC that is usual in APL patients and should be better to be used with other therapeutic methods.

 

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Published
2020-04-07
How to Cite
1.
Mohammadi Kanesbi M, Jarahi L, Keramati MR. Blood Parameters in Treatment with Arsenic Trioxide in Acute Promyelocytic Leukemia: A Systematic Review. Int J Hematol Oncol Stem Cell Res. 14(2):130-139.
Section
Review Article(s)