Aberrant Phenotypes in Acute Myeloid Leukemia and Its Relationship with Prognosis and Survival: A Systematic Review and Meta-Analysis

a systematic review and meta-analysis

  • Lucio Henrique Sousa Pinheiro ORCID Department of Pharmacy, Laboratory of Hematology, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil
  • Louise Dantas Trindade Department of Pharmacy, Laboratory of Hematology, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil
  • Fernandes de Oliveira Amanda Costa ORCID Department of Medicine, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
  • Nathanielly de Lima Silva ORCID Department of Pharmacy, Laboratory of Hematology, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil
  • Alex Freire Sandes ORCID Department of Medicine, Hematology Course, Federal University of São Paulo, São Paulo, São Paulo, Brazil
  • Marco Antônio Prado Nunes ORCID Department of Medicine, Federal University of Sergipe, Aracaju, Sergipe, Brazil
  • Cristiane Bani Correa ORCID Department of Morphology, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil
  • Carlos Arthur Cardoso Almeida ORCID Nursing and Pharmacy School, Federal University of Alagoas, Maceió, Alagoas, Brazil
  • Geydson Silveira da Cruz ORCID Hematologist, University Hospital, Federal University of Sergipe, Aracaju, Sergipe, Brazil
  • Divaldo Pereira de Lyra Júnior ORCID Department of Pharmacy, Laboratory of Hematology, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil
  • Dulce Marta Shimieguel Mail Department of Pharmacy, Laboratory of Hematology, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil
Keywords:
Aberrant phenotype, Acute myeloid leukemia, Immunophenotyping, Prognosis, Survival

Abstract

Background: The aim of this review was to evaluate the influence of aberrant phenotypes in prognosis and survival in acute myeloid leukemia (AML) patients by multiparametric flow cytometry.

Materials and Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a review of PubMed, Scopus, Science Direct and Web of Science was carried out through 1998 to 2016, conducted by two reviewers independently, evaluating titles, abstracts and full-texts of the selected studies.

Results: Ten studies were included on this review, in which the aberrant phenotype expression of 17 markers were detected in AML patients. From these, 11 aberrant phenotypes were associated with prognosis, which eight had shown negative impact on prognosis: CD7, CD56, CD15, CD2, CD3, CD90low, CD123high, CD117high, and three others were associated with good prognosis: CD19, CD98high and CD117+/CD15+. Meta-analysis showed that aberrant expression of CD56 as a poor prognostic marker with unfavorable outcomes is implicated in decreased overall survival in AML patients in 28 months (95% CI: 0.62 to 0.92).

Conclusion: This was observed when there was association between CD56 expression and other prognostic factors, influencing on patients’ management care and treatment.

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Published
2020-10-07
How to Cite
1.
Pinheiro LHS, Trindade L, Costa F de OA, Silva N de L, Sandes AF, Nunes MAP, Correa CB, Almeida CAC, Cruz GS da, Lyra Júnior DP de, Shimieguel DM. Aberrant Phenotypes in Acute Myeloid Leukemia and Its Relationship with Prognosis and Survival: A Systematic Review and Meta-Analysis. Int J Hematol Oncol Stem Cell Res. 14(4):274-288.
Section
Original Article(s)