The Diagnostic Value of Ultrasound-Guided Cervical Core Needle Biopsy in Diagnosis of Lymphoma in Suspected Patients
Background: Core needle biopsy (CNB) guided by imaging modalities seems to be an acceptable modality for diagnosis of lymphoma due to its safety, good applicability, availability as well as diagnostic accuracy, however; Studies have not reached a consensus on its diagnostic accuracy and factors affecting its performance. The present study aimed to assess the value of ultrasound-guided cervical CNB in the diagnosis of lymphoma in suspected patients.
Materials and Methods: This cross-sectional study was performed on 46 consecutive patients (20 to 82 years) with cervical mass or lymphadenopathy suspected of lymphoma and were candidates for diagnostic evaluation. Ultrasound-guided core needle biopsies (UGCNB) were done by a single radiologist under guided ultrasonography. The diagnostic value of UGCNB in the diagnosis and determination of specific lymphoma subtypes was assessed.
Results: Using UGCNB led to the diagnosis of lymphoma in 34.8% and non-lymphoma lesions in 43.5%, while the diagnosis remained unclear in other 21.7% with a total UGCNB-based identification rate of 78.3%. No patient with lymphoma was missed. All patients were followed up over a 6-month period. In none of the cases, clinical diagnosis and treatment response were found contrary to the initial pathologic diagnosis. No significant complication such as hematoma or infection was reported.
Conclusion: UGCNB has a high diagnostic value for determining the nature of the cervical lesions suspected of lymphoma.
2. Dorfman T, Neymark M, Begal J, et al. Surgical Biopsy of Pathologically Enlarged Lymph Nodes: A Reappraisal. Isr Med Assoc J. 2018;20(11):674-678.
3. Bosch X, Coloma E, Donate C, et al. Evaluation of unexplained peripheral lymphadenopathy and suspected malignancy using a distinct quick diagnostic delivery model: prospective study of 372 patients. Medicine (Baltimore). 2014;93(16):e95.
4. Volk GF, Guntinas-Lichius O, Geißler K. Core needle biopsy. Laryngorhinootologie. 2015;94(10):658-9.
5. Eric de Kerviler, Cédric de Bazelaire, Nicolas Mounier, et al. Image-guided core-needle biopsy of peripheral lymph nodes allows the diagnosis of lymphomas. Eur Radiol. 2007;17(3):843–9.
6. Demharter J, Neukirchen S, Wagner T, et al. [Do ultrasound-guided core needle biopsies of lymph nodes allow for subclassification of malignant lymphomas?]. Rofo. 2007;179(4):396–400.
7. Kwon M, Yim C, Baek HJ, et al. Ultrasonography-guided core needle biopsy of cervical lymph nodes for diagnosing head and neck lymphoma compared with open surgical biopsy: Exploration for factors that shape diagnostic yield. Am J Otolaryngol. 2018;39(6):679-684.
8. Oh KH, Woo JS, Cho JG, et al. Efficacy of ultrasound-guided core needle gun biopsy in diagnosing cervical lymphadenopathy. Eur Ann Otorhinolaryngol Head Neck Dis. 2016;133(6):401-404.
9. Hehn ST, Grogan TM, Miller TP. Utility of fine-needle aspiration as a diagnostic technique in lymphoma. J Clin Oncol. 2004;22(15):3046–52.
10. Sklair-Levy M, Polliack A, Shaham D, et al. CT-guided core-needle biopsy in the diagnosis of mediastinal lymphoma. Eur Radiol. 2000;10(5):714–8.
11. de Kerviler E, Guermazi A, Zagdanski AM, et al. Image-guided core-needle biopsy in patients with suspected or recurrent lymphomas. Cancer. 2000;89(3):647–52.
12. Demharter J, Muller P, Wagner T, et al. Percutaneous core-needle biopsy of enlarged lymph nodes in the diagnosis and subclassification of malignant lymphomas. Eur Radiol. 2001;11(2):276–83.
13. Ganott MA, Zuley ML, Abrams GS, et al. Ultrasound guided core biopsy versus fine needle aspiration for evaluation of axillary lymphadenopathy in patients with breast cancer. ISRN Oncol. 2014;2014:703160.
14. He Y, Ji X, Xie Y, et al. Clinical application of ultrasound guided core needle biopsy with multiple punches in the diagnosis of lymphoma. World J Surg Oncol. 2015;13:126.
15. Li L, Wu QL, Liu LZ, et al. Value of CT-guided core-needle biopsy in diagnosis and classification of malignant lymphomas using automated biopsy gun. World J Gastroenterol. 2005;11(31):4843-7.
16. Lachar WA, Shahab I, Saad AJ. Accuracy and cost-effectiveness of core needle biopsy in the evaluation of suspected lymphoma: a study of 101 cases. Arch Pathol Lab Med. 2007;131(7):1033-9.
17. Wilczynski A, Görg C, Timmesfeld N, et al. Value and Diagnostic Accuracy of Ultrasound-Guided Full Core Needle Biopsy in the Diagnosis of Lymphadenopathy: A Retrospective Evaluation of 793 Cases. J Ultrasound Med. 2020;39(3):559-567.
18. Feng H, Min X, Ting X, et al. Efficacy of ultrasound-guided core needle biopsy in cervical lymphadenopathy: A retrospective study of 6,695 cases. Eur Radiol. 2018;28(5):1809-1817.
19. Qinglong H, Naushad H, Qingmei X, et al. Needle-Core Biopsy in the Pathologic Diagnosis of Malignant Lymphoma Showing High Reproducibility Among Pathologists. Am J Clin Pathol. 2013;140(2):238-47.
20. Groneck L, Quaas A, Hallek M, et al. Ultrasound-guided core needle biopsies for workup of lymphadenopathy and lymphoma. Eur J Haematol. 2016;97(4):379-86.
21. Pedote P, Gaudio F, Moschetta M, et al. Ct-guided needle biopsy performed with modified coaxial technique in the diagnosis of malignant lymphomas. Radiol Med. 2010;115(8):1292–303.
22. Loubeyre P, McKee TA, Copercini M, et al. Diagnostic precision of image-guided multisampling core needle biopsy of suspected lymphomas in a primary care hospital. Br J Cancer. 2009;100(11):1771–6.
|Issue||Vol 16, No 2 (2022)|
|Lymphoma; Ultrasound-guided core needle biopsies (USGCNB); Lymphadenopathy|
|Rights and permissions|
|This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.|