Original Article

Pediatric Cancer Registry at MAHAK Pediatric Cancer Treatment and Research Center: A Single-Center Study from Iran

Abstract

Background: The childhood cancer registry in Iran is a hospital-based system and there is not any unique and national registry system for pediatric malignancies in Iran. According to the limitations and requirements, this study was designed to clarify the aspect of childhood malignancies in Iran and promote establishing the Iranian national childhood cancer registry system. 

Materials and Methods: This cross-sectional longitudinal study was implied on 1500 patients younger than 20-years old diagnosed with any malignancy and admitted at MAHAK Pediatric Cancer Treatment and Research Center (MPCTRC) from 2007 to 2014. Data collection was based on a validated questionnaire with three categories including demographic data, clinical data and type of malignancy, and outcomes. Collected data were analyzed using methods for qualitative and quantitative variables (P-Value < 0.05) by SPSS software version 22. The survival rate was calculated by the Kaplan-Meyer method.     

Results: This study was implied on 1500 children with a mean age of 6.1 years old. The most common malignancy was acute leukemia (30.7%) followed by central nervous system tumors (27%). At the onset of starting treatment, the rate of conferring with relapse, metastasis, and secondary malignancies was 29%, 19.5%, and 1% respectively. In addition, 52 patients had bone marrow transplantation of whom, 14 cases died. Totally, 42% of patients died and the 3-years, 5-years, and 10-years overall survival rates were 67.7% ± 0.01, 60.3% ± 0.01, and 53.8% ± 0.01, respectively.

Conclusion: Establishing a population-based pediatric cancer registry in Iran is necessary and will be useful for improving the survival rate of mentioned patients. 

 

1. Steliarova-Foucher E, Colombet M, Ries LA, et al. International incidence of childhood cancer, 2001–10: a population-based registry study. Lancet Oncol. 2017;18(6):719-31.
2. Magrath I, Steliarova-Foucher E, Epelman S, et al. Paediatric cancer in low-income and middle-income countries. Lancet Oncol. 2013;14(3):e104-e16.
3. The World Bank. World development indicators [Available from: http://databank.worldbank.org/data/home.aspx.
4. Smith MA, Seibel NL, Altekruse SF, et al. Outcomes for children and adolescents with cancer: challenges for the twenty-first century. J Clin Oncol. 2010;28(15):2625.
5. Hershman DL, Wright JD. Comparative effectiveness research in oncology methodology: observational data. J Clin Oncol. 2012;30(34):4215-22.
6. Fedorovsky JM, Cuervo LG, Luciani S. Pediatric cancer registries in Latin America: the case of Argentina's pediatric cancer registry. Rev Panam Salud Públ/Pan Am. 2018;41:e152.
7. Robinson D, Sankila R, Hakulinen T, Møller H. Interpreting international comparisons of cancer survival: the effects of incomplete registration and the presence of death certificate only cases on survival estimates. Eur J Cancer. 2007;43(5):909-13.
8. Johnston W, Erdmann F, Newton R, Steliarova-Foucher E, Schüz J, Roman E. Childhood cancer: Estimating regional and global incidence. Cancer Epidemiol. 2020:101662.
9. Becker C, Graf N, Grabow D, et al. Early deaths from childhood cancer in Germany 1980-2016. Cancer Epidemiol. 2020;65:101669.
10. Shabani M, Saeedi Moghaddam S, Ataeinia B, et al. Trends of National and Subnational Incidence of Childhood Cancer Groups in Iran: 1990–2016. Front Oncol. 2020;9:1428.
11. Schindler M, Mitter V, Bergstraesser E, Gumy-Pause F, Michel G, Kuehni CE. Death certificate notifications in the Swiss Childhood Cancer Registry: assessing completeness and registration procedures. Swiss Med Wkly. 2015;145:w14225.
12. Mitter VR, Michel G, Wölfli P, et al. Swiss Childhood Cancer Registry: Annual Report 2011/2012. 2013.
13. World Health Organization. International statistical classification of diseases and related health problems: 10th revision (ICD-10). Available from: http://www.who int/classifications/apps/icd/icd.
14. Kaatsch P. Epidemiology of childhood cancer. Cancer Treat Rev. 2010;36(4):277-85.
15. Pandey A, Singh A, Kumar V, et al. Pediatric cancers in Bihar: A retrospective tertiary cancer center study. South Asian J Cancer. 2020;9(1):53.
16. Piñeros M, Znaor A, Mery L, Bray F. A global cancer surveillance framework within noncommunicable disease surveillance: making the case for population-based cancer registries. Epidemiol Rev. 2017;39(1):161-9.
17. Freddie Bray, Ariana Znaor, Patricia Cueva, et al. (2014). Planning and developing population-based cancer registration in low- and middle-income settings. Lyon, France: International Agency for Research on Cancer (IARC Technical Publication No. 43).
18. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7-34.
19. Baliga S, Yock TI. Pediatric Cancer. Hematol Oncol Clin North Am. 2020;34(1):143-59.
20. DeSantis CE, Lin CC, Mariotto AB, et al. Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin. 2014;64(4):252-71.
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IssueVol 16, No 2 (2022) QRcode
SectionOriginal Article(s)
DOI https://doi.org/10.18502/ijhoscr.v16i2.9201
Keywords
Cancer registry; Iran, Pediatrics; Childhood cancer
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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Faranoush M, Mehrvar N, Sadeghi Y, Tashvighi M, Alebouyeh M, Mehrvar A. Pediatric Cancer Registry at MAHAK Pediatric Cancer Treatment and Research Center: A Single-Center Study from Iran. Int J Hematol Oncol Stem Cell Res. 2022;16(2):86-93.