Vertebra Plana Caused by Malignant Lymphoma (A case report)
Abstract
Vertebra plana is a radiological diagnosis that indicates complete compression of the vertebral body.(1,2) This condition was reported in Langerhans cell histiocytosis including eosino-philic granuloma,(3, 12) Ewing's sarcoma,(2,13,14) tuberculosis,(15,16) vertebral osteomyelitis,(17) aseptic necrosis,(18) aneurysmal bone cyst,(19) osteosarcoma,(20) neuroblastoma,(21) acute leu-kemia,(22) rhabdomyosarcoma(23) and some other diseases.(25-30) There have been rare reports of vertebra plana due to malignant lymphoma.(23,24) Herein, we report a case of a 13 year-old boy with vertebra plana due to malignant lymphoma and describe his clinical manifestations, histological features, diagnosis, managment and clinical course.
- Renton P. Avascular necrosis; osteochondritis; mis- cellaneous bone lesions. In: sutton D. Textbook of radi- ology and imaging. Newyork, PA: Churchill livingstone; 2003:1187.
- Papagelopoulos PJ, Currier BL, Galanis E, et al. Vertebra plana caused by primary Ewing sarcoma: Case report and review of the literature. J spinal Disord Tech. 2002; 15(3): 252-257.
- Kieffer SA, Nesbit ME, DAgio GJ. Vertebra plana due to histiocytosis X: Serial studies. Acta Radiol Diagn (stockh). 1969; 8(3): 241-250.
- Garg S, Mehta S, Dormans JP. An Atypical presen- tation of langerhans cell histiocytosis of the cervical spine in a child. spine. 2003; 28(21): 445-448.
- Levine SE, Dorman’s JP, Meyer JS et al. Langer- hans cell histiocytosis of the spine in children. clin Or- thop. 1996; 323: 288-293.
- Greinacher I, Gutjahr P. Vertebral changes in histiocytosis X. Radiologe. 1978; 18(6): 228-232.
- Sherk HH, Nicholson JT, Nixon JE. Vertebra plana and eosinophilic granuloma of the cervical spine in chil- dren. spine. 1978; 3(2): 116-121.
- Reddy PK, Vannemreddy PS, Nanda A. Eosino- philic granuloma of spine in adults: a case report and re- view of literature. spinal cord. 2000; 38(12): 766-768.
- Villas C, Martinez–Peric R, Barrios RH, et al. Eosi- nophilic granuloma of the spine with and without verte- bra plana : Long–term follow-up of six cases. J spinal disord. 1993; 6(3): 260-268.
- Bertram C, Madert J, Eggers C. Eosinophilic granu- loma of the cervical spine. spine. 2002; 27(13): 1408- 1413.
- Floman Y, Bar –On E, Mosheiff R Mirovsky Y, et al. Eosinophilic granuloma of the spine . J Pediatr orthop B. 1997; 6(4): 260-265.
- Immenkamp M. Eosinophilic granuloma of the spine . Z orthop Ihre Grenzgeb. 1985; 123(2): 227-234.
- Emir S, Akyuz C, Yazici M, et al. Vertebra plana as a manifestation of Ewing sarcoma in a child. Med Pediatr Oncol. 1999; 33(6): 594-595.
- Kager L, Zoubek A, Kotz R, et al . vertebra plana due to a Ewing tumor. Med Pediatr Oncol. 1999; 32(1): 57-59.
- Galland M. True tuberculous vertebra plana. Rev chir orthop Reparatrice Appar Mot. 1956; 42(2): 352- 356.
- Galland M, Houpis. vertebra plana and protoverte- bra in pott’s disease. Rev chir orthop Reparatrice Appar Mot.1955; 41(2): 225-233.
- Yu L, Kasser JR, O'Rourke E, et al. Chronic recur- rent multifocal osteomyelitis. Association with vertebra plana. J Bone Joint Surg Am 1989; 71:105–12 Sited from Papagelopoulos PJ, Currier BL, Galanis E, et al. Vertebra plana caused by primary Ewing sarcoma: Case report and review of the literature. J spinal Disord Tech. 2002; 15(3): 252-257.
- Jani L, Suezawa Y, Kaufmann L. Aseptic necroses of the spine: differential diagnosis and treatment of the vertebra plana [in German]. Orthopade 1981; 10:40–4 sited from Papagelopoulos PJ, Currier BL, Galanis E, et al. Vertebra plana caused by primary Ewing sarcoma: Case report and review of the literature. J spinal Disord Tech. 2002; 15(3): 252-257.
- Papagelopoulos PJ, Currier BL, Galanis EC, et al. vertebra plana of the lumbar spine caused by an aneury- mal bone cyst: a case report . Am J orthop 1999; 28(2): 119-124.
- Baghaie M, Gillet P, Dondelinger RF, et al. Verte- bra plana: benign or malignant lesion? Pediatr Radiol 1996; 26:431–3 Sited from Papagelopoulos PJ, Currier BL, Galanis E, et al. Vertebra plana caused by primary Ewing sarcoma: Case report and review of the literature. J spinal Disord Tech. 2002; 15(3): 252-257.
- O'Donnell J, Brown L, Herkowitz H. Vertebra plana-like lesions in children: case report with special emphasis on the differential diagnosis and indications for biopsy. J Spinal Disord 1991; 4:480–5 Sited from Pa- pagelopoulos PJ, Currier BL, Galanis E, et al. Vertebra plana caused by primary Ewing sarcoma: Case report and review of the literature. J spinal Disord Tech. 2002; 15(3): 252-257.
- Buhr J. Differential diagnosis of vertebra plana: Iso- lated flat vertebra as an early symptom of acute leukemia. kinderaztl prax. 1970; 38(6): 259-266.
- Kosenow W, Niederle J. Roentgenologic spinal changes in malignant tumors in childhood [in German]. Monatsschr Kinderheilkd 1972; 120:1–8 Sited from Pa- pagelopoulos PJ, Currier BL, Galanis E, et al. Vertebra plana caused by primary Ewing sarcoma: Case report and review of the literature. J spinal Disord Tech. 2002; 15(3): 252-257.
- Solgaard S, kristiansen B .Vertebra plana due to a malignant lymphoma. Acta Orthop Scand . 1980; 51(2): 267-269.
- Calvé J. A localized affection of the spine suggest- ing osteochondritis of the vertebral body, with the clini- cal aspect of Pott's disease. J Bone Joint Surg 1925; 7:41–6 Sited from Papagelopoulos PJ, Currier BL, Galanis E, et al. Vertebra plana caused by primary Ewing sarcoma: Case report and review of the literature. J spinal Disord Tech. 2002; 15(3): 252-257.
- Kozlowski K. Platyspondyly in childhood. Pediatr Radiol 1974; 2:81–7 sited from Papagelopoulos PJ, Cur- rier BL, Galanis E, et al. Vertebra plana caused by pri- mary Ewing sarcoma: Case report and review of the lit- erature. J spinal Disord Tech. 2002; 15(3): 252-257.
- Schumacher R, Muller U, Schuster W. Rare local- isation of osteochondrosis juvenilis [in German]. Ra- diologe 1981; 21:165–74 sited from Papagelopoulos PJ, Currier BL, Galanis E, et al. Vertebra plana caused by primary Ewing sarcoma: Case report and review of the literature. J spinal Disord Tech. 2002; 15(3): 252-257.
- Hill SC, Parker CC, Brady RO, et al. MRI of multi- ple platyspondyly in Gaucher disease: response to en- zyme replacement therapy. J Comput Assist Tomogr 1993; 17:806–9 Sited from Papagelopoulos PJ, Currier BL, Galanis E, et al. Vertebra plana caused by primary Ewing sarcoma: Case report and review of the literature. J spinal Disord Tech. 2002; 15(3): 252-257.
- Nykamp PW. Vertebra plana: two cases due to dis- seminated coccidioidomycosis. Ariz Med 1971; 28:165–7 Sited from Papagelopoulos PJ, Currier BL, Galanis E, et al. Vertebra plana caused by primary Ewing sarcoma: Case report and review of the literature. J spinal Disord Tech. 2002; 15(3): 252-257.
- Dautenhahn L, Blaser SI, Weitzman S, Crysdale WS. Infantile myofibromatosis: A cause of vertebra plana. AJNR Am J Neuroradiol 1995; 16(suppl):828–30 Sited from Papagelopoulos PJ, Currier BL, Galanis E, et al. Vertebra plana caused by primary Ewing sarcoma: Case report and review of the literature. J spinal Disord Tech. 2002; 15(3): 252-257.
- Buchman J. Osteochondritis of vertebral body. J Bone Joint Surg 1927; 9:55–66 Sited from Papagelopou- los PJ, Currier BL, Galanis E, et al. Vertebra plana caused by primary Ewing sarcoma: Case report and re- view of the literature. J spinal Disord Tech. 2002; 15(3): 252-257.
- Powell T. The spine . In: chapman s, Nakielny R. Aids to radiological differential diagnosis , London , PA: Saunders; 1995: 78.
Files | ||
Issue | Vol 1, No 2 (2004) | |
Section | Articles | |
Keywords | ||
#No Keywords# |
Rights and permissions | |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |