Original Article

A Study of Association of ABO and Rh Blood Group with Colorectal Cancer in Khuzestan Province, Iran

Abstract

Background: Colorectal cancer, a solid tumor with a high prevalence, contributes significantly to annual mortality rates. Various factors, including blood groups, may influence cancer risk. Multiple studies have suggested a potential connection between ABO and Rh blood groups and colorectal cancer risk. This study aims to investigate the role of ABO and Rh blood groups as risk factors in colorectal cancer patients.
Materials and Methods: We conducted a retrospective study involving 71 colorectal cancer patients diagnosed between 2018 and 2020 in Khuzestan province, Iran, with known ABO blood types. Large-scale data from 29,922 blood donors in Khuzestan served as the healthy population control. The study analyzed the distribution of ABO blood groups among the blood donors.
Results: Our findings revealed that the distribution of blood groups
among colorectal cancer patients was as follows: O (31.0%), A (29.6%), B (29.6%), and AB (9.8%). However, our analysis did not establish a significant association between colorectal cancer risk and ABO antigens (P-value = 0.636) or Rh blood group (P = 0.198). Additionally, no significant differences in ABO blood types were observed concerning gender (P = 0.802), cancer type (P = 0.338), or tumor type (P = 0.207) among colorectal cancer patients.
Conclusion: This study does not support a significant correlation between ABO and Rh blood groups and the risk of colorectal cancer, nor does it find associations with cancer type or tumor type.

1. Cao X, Wen Z, Sun Y, et al. Prognostic value of ABO blood group in patients with surgically resected colon cancer. Br J Cancer. 2014;111(1):174-80.
2. Wei J, Zhang Y, Zheng J, et al. Prognostic value of ABO blood group in a Chinese population in Northwest China region with curatively resected rectal cancer. J Cancer. 2019;10(26):6584-6593.
3. Kashfi SM, Bazrafshan MR, Kashfi SH, et al. The relationship between blood group and colon cancer in Shiraz Namazi Hospital During 2002-2011. Jundishapur Journal of Chronic Disease Care. 2018;7(1):
4. Hsiao LT, Liu NJ, You SL, et al. ABO blood group and the risk of cancer among middle‐aged people in Taiwan. Asia Pac J Clin Oncol. 2015;11(4):e31-6.
5. Celić D, Lipozenčić J, Kolarić B, et al. Association between blood group and nonmelanoma skin cancers (Basal Cell Carcinoma and Squamous Cell Carcinoma). Int J Environ Res Public Health. 2019;16(13):2267.
6. Fotra R, Gupta S, Raina T, et al. Association of ABO and Rh Blood Groups With the Carcinoma of the Cervix With Special Reference to Jammu Region. Biosci Biotechnol Res Asia. 2011;8(1):313-316.
7. Montavon Sartorius C, Schoetzau A, Kettelhack H, et al. ABO blood groups as a prognostic factor for recurrence in ovarian and vulvar cancer. PLoS One. 2018;13(3):e0195213.
8. Saxena S, Chawla VK, Gupta KK, et al. Association of ABO blood group and breast cancer in Jodhpur. Indian J Physiol Pharmacol. 2015;59(1):63-8.
9. Saxena S, Gupta KK. Association of ABO blood groups in relation to gastrointestinal cancers in Jodhpur. Sch J App Med Sci. 2017;5(10C):4013-8.
10. Singh V, Yadav U, Rai V, et al. A Study of Association of ABO Blood Group types with Cancer Risk. bioRxiv. 2019:796284.
11. Tam AA, Özdemir D, Fakı S, et al. ABO Blood Groups, Rh Factor, and Thyroid Cancer Risk: To ‘B’or Not to ‘B’. Endocr Res. 2020;45(2):137-146.
12. Paridar M, Shoushtari MM, Kiani B, et al. Distribution of ABO blood groups and rhesus factor in a Large Scale Study of different cities and ethnicities in Khuzestan province, Iran. Egypt J Med Hum Genet. 2016;17(1):105-9.
13. Kerimov RA, Seksenbaev BD, Galimov OV,et al. The results of the study of blood group and colorectal cancer interrelation. Creat Surg Oncol. 2017;7(4):32-7.
14. Kahramanca Ş, Anuk T, Ali CY, et al. Blood group characteristics in colorectal cancers. Turk J Colorectal Dis. 2018;28(2):76-79
15. Urun Y, Ozdemir NY, Utkan G, et al. ABO and Rh blood groups and risk of colorectal adenocarcinoma. Asian Pac J Cancer Prev. 2012;13(12):6097-100.
16. Khalili H, Wolpin BM, Huang ES, et al. ABO blood group and risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2011;20(5):1017-20.
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IssueVol 17, No 4 (2023) QRcode
SectionOriginal Article(s)
DOI https://doi.org/10.18502/ijhoscr.v17i4.13919
Keywords
ABO blood-group system; Rh-Hr blood-group system; Colorectal neoplasms; Risk factors; Solid tumors
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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Jodat H, Jodat J, Khodadadi A, Talaiezadeh A, Joudaki N, Asadirad A. A Study of Association of ABO and Rh Blood Group with Colorectal Cancer in Khuzestan Province, Iran. Int J Hematol Oncol Stem Cell Res. 2023;17(4):275-280.