Pure Biclonal Hairy Cell Leukemia–Apt Diagnosis with Multicolor Flow Cytometry
Biclonal Hairy Cell Leukemia
Abstract
Hairy cell leukemia (HCL) is a rare B-cell neoplasm that constitutes around 2 percent of all lymphoid leukemias and occurs more frequently in elderly males. The usual triad of HCL includes pancytopenia, splenomegaly, and hairy cells in the bone marrow. This is a case of an atypical presentation of biclonal HCL diagnosed on flow cytometry; the existence of biclonal HCL is extremely rare with very few case reports. Pure biclonal HCL should be regarded as an extraordinary finding among the so-called composite lymphomas.
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5. Raghavachar A, Bartram C, Porzsolt F. Eradication by alpha-interferon of one clone in biclonal hairy cell leukaemia. The Lancet. 1986; 328(8505):516.
2. Tiacci E, De Carolis L, Simonetti E, et al. Safety and efficacy of the BRAF inhibitor dabrafenib in relapsed or refractory hairy cell leukemia: a pilot phase-2 clinical trial. Leukemia. 2021; 35(11):3314-8.
3. Mahdi T, Rajab A, Padmore R, et al. Characteristics of lymphoproliferative disorders with more than one aberrant cell population as detected by 10‐color flow cytometry. Cytometry Part B: Clinical Cytometry. 2018; 94(2):230-8.
4. Vittoria L, Bozzi F, Capone I, et al. A rare biclonal Hairy Cell Leukemia disclosed by an integrated diagnostic approach: A case report. 2020.
5. Raghavachar A, Bartram C, Porzsolt F. Eradication by alpha-interferon of one clone in biclonal hairy cell leukaemia. The Lancet. 1986; 328(8505):516.
| Files | ||
| Issue | Vol 18 No 4 (2024) | |
| Section | Case Report(s) | |
| DOI | https://doi.org/10.18502/ijhoscr.v18i4.16764 | |
| Keywords | ||
| Biclonal; Hairy cell; Leukemia; Flow cytometry | ||
| Rights and permissions | |
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Adnan S, Farrukh S, Ahmed A, Shaikh MS. Pure Biclonal Hairy Cell Leukemia–Apt Diagnosis with Multicolor Flow Cytometry. Int J Hematol Oncol Stem Cell Res. 2024;18(4):401-403.
