Original Article

The Relationship between the Lifestyle of the Allogeneic Stem Cell Donors and the Number of Donated CD34+ and CD3+ Cells

Abstract

Background: Hematopoietic stem cell transplantation (HSCT) is considered as the last treatment option for many life-threatening diseases. The number of donated cells can affect transplantation success. This study attempted to investigate the relationship between the health-promoting lifestyle of allogeneic stem cell donors and the number of donated CD34+ and CD3+ cells.
Materials and Methods: The study was a descriptive correlational study in which 100 peripheral blood stem cell donors participated. A demographic form and health-promoting lifestyle profile-II questionnaire were distributed to participants, and then cell separation was started. Afterward, the results of CD34 + and CD3 + cell counts, as well as other clinical parameters of the participants, were recorded. The collected data were analyzed by descriptive and analytical statistical methods.
Results:  The results showed that the mean total health-promoting lifestyle profile score for hematopoietic stem cell donors was 2.876±0.461. There was no significant relationship between the health-promoting lifestyle score and the number of CD34+, CD3+ cells and CD3+/CD34+ ratio. A positive and significant correlation was found between the weight of the donors and the number of CD34+ (P < 0.001) and CD3+ cells (P = 0.001). The number of CD34+ cells was significantly different between women and men (P = 0.009).
Conclusion: Lifestyle had no significant effect on the number of CD3+/CD34+ cells. Moreover, the number of CD34+ cells was significantly higher in men, so males should be preferentially recruited as donors for the HSCT procedure.

 

1. Niederwieser D, Baldomero H, Szer J, et al. Hematopoietic stem cell transplantation activity worldwide in 2012 and a SWOT analysis of the Worldwide Network for Blood and Marrow Transplantation Group including the global survey. Bone Marrow Transplant. 2016;51(6):778-85.
2. Yokohama A, Yokote K, Maruhashi T. Apheresis on aged patients/donors with complicated backgrounds like ischemic heart disease, arrhythmia, and others. Transfus Apher Sci. 2018;57(5):619-22.
3. Chen SH, Wang TF, Yang KL. Hematopoietic stem cell donation. Int J Hematol. 2013; 97(4):446-55.
4. Martino M, Gori M, Pitino A, et al. Basal CD34+ Cell Count Predicts Peripheral Blood Stem Cell Mobilization in Healthy Donors after Administration of Granulocyte Colony–Stimulating Factor: A Longitudinal, Prospective, Observational, Single-Center, Cohort Study. Biol Blood Marrow Transplant. 2017;23(7):1215-20.
5. Kamel A, El-Sharkawy N, Mahmoud H, et al. Impact of CD34 subsets on engraftment kinetics in allogeneic peripheral blood stem cell transplantation. Bone Marrow Transplant. 2005;35(2):129-36.
6. Anderlini P, Przepiorka D, Lauppe J, et al. Collection of peripheral blood stem cells from normal donors 60 years of age or older. Br J Haematol. 1997;97(2):485-7.
7. Zhen C, Fang X, Ding M, et al. Smoking is an important factor that affects peripheral blood progenitor cells yield in healthy male donors. J Clin Apher. 2020;35(1):33-40.
8. Larijani TT, Mohammadi S, Kasaeian A, et al. How do anxiety affect CD34 and CD3 cells in allogeneic peripheral blood stem cell transplantation? Transfus Apher Sci. 2018;57(1):107-10.
9. Yan L, Yingjun C, Lanping X, et al. Negative association of donor age with CD34+ cell dose in mixture allografts of G-CSF-primed bone marrow and G-CSF-mobilized peripheral blood harvests. Chin Med J (Engl). 2014; 127(20):3597-601.
10. Lown RN, Philippe J, Navarro W, et al. Unrelated adult stem cell donor medical suitability: recommendations from the World Marrow Donor Association Clinical Working Group Committee. Bone Marrow Transplant. 2014;49(7):880-6.
11. Sacchi N, Costeas P, Hartwell L, et al. Haematopoietic stem cell donor registries: World Marrow Donor Association recommendations for evaluation of donor health. Bone Marrow Transplant. 2008;42(1):9-14.
12. De Groot R. Associations of environmental characteristics and lifestyle behaviours with donor blood parameters: PhD-Thesis - Research and graduation internal, Vrije Universiteit Amsterdam, 2020.
13. Fleischhacker SE, Evenson KR, Rodriguez DA, et al. A systematic review of fast food access studies. Obes Rev. 2011; 12(5):e460-e71.
14. Kent J, Thompson S. Health and the built environment: exploring foundations for a new interdisciplinary profession. J Environ Public Health. 2012:212: 958175.
15. Srof BJ, Velsor-Friedrich B. Health promotion in adolescents: a review of Pender's health promotion model. Nurs Sci Q. 2006; 19(4):366-73.
16. Rastegar M, Zendehtalab H, Yavari M, et al. Health-promoting lifestyle and its related factors among health volunteers Mashhad in 2015. Journal of Torbat Heydariyeh University of Medical Sciences. 2015;3(3): 48-55.
17. Kaastrup K, Grønbæk K. The Impact of Sedentary Lifestyle, High-fat Diet, Tobacco Smoke, and Alcohol Intake on the Hematopoietic Stem Cell Niches. Hemasphere. 2021; 5(8):e615.
18. Shaw J. Linking Lifestyle to Stem Cells. 2020. Available at: https://www.harvardmagazine.com/2020/05/right-now-linking-lifestyle-to-stem-cells. Access date: 2023.
19. Stover P, Field M, Brawley H, et al. Nutrition and stem cell integrity in aging. J Intern Med. 2022; 292(4):587-603.
20. Walker SN, Sechrist KR, Pender NJ. The health-promoting lifestyle profile: development and psychometric characteristics. Nurs Res. 1987;36(2):76-81.
21. Mohammadi Zeidi I, Pakpour Hajiagha A, Mohammadi Zeidi B. Reliability and Validity of Persian Version of the Health-Promoting Lifestyle Profile. J Mazandaran Univ Med Sci. 2011;20(1):102-13.
22. Pinar R, Celik R, Bahcecik N. Reliability and construct validity of the Health-Promoting Lifestyle Profile II in an adult Turkish population. Nurs Res. 2009;58(3):184-93.
23. Kong JH, Hu Y, Shim H, et al. Analysis of factors associated with successful allogeneic peripheral blood stem cell collection in healthy donors. Transfus Apher Sci. 2020;59(2):102679.
24. Pulsipher MA, Logan BR, Chitphakdithai P, et al. Effect of Aging and Predonation Comorbidities on the Related Peripheral Blood Stem Cell Donor Experience: Report from the Related Donor Safety Study. Biol Blood Marrow Transplant. 2019;25(4):699-711.
25. Wang TF, Wen SH, Chen RL, et al. Factors Associated with Peripheral Blood Stem Cell Yield in Volunteer Donors Mobilized with Granulocyte Colony-Stimulating Factors: The Impact of Donor Characteristics and Procedural Settings. Biol Blood Marrow Transplant. 2008;14(11):1305-11.
26. Jabłoński M, Mazur JK, Tarnowski M, et al. Mobilization of peripheral blood stem cells and changes in the concentration of plasma factors influencing their movement in patients with panic disorder. Stem Cell Rev Rep. 2017;13(2):217-25
27. Farhadfar N, Ahn KW, Bo-Subait S, et al. The Impact of Pre-Apheresis Health Related Quality of Life on Peripheral Blood Progenitor Cell Yield and Donor's Health and Outcome: Secondary Analysis of Patient-Reported Outcome Data from the RDSafe and BMT CTN 0201 Clinical Trials. Transplant Cell Ther. 2022;28(9): 603.e1-603.e7.
28. Lysák D, Koza V, Jindra P. Factors affecting PBSC mobilization and collection in healthy donors. Transfus Apher Sci. 2005;33(3):275-83.
Files
IssueVol 18 No 3 (2024) QRcode
SectionOriginal Article(s)
DOI https://doi.org/10.18502/ijhoscr.v18i3.16101
Keywords
Hematopoietic stem cell transplantation Stem cell Collection Lifestyle; Donor
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Sayadi L, Mohammadi S, Aminian P. The Relationship between the Lifestyle of the Allogeneic Stem Cell Donors and the Number of Donated CD34+ and CD3+ Cells. Int J Hematol Oncol Stem Cell Res. 2024;18(3):210-219.