Articles

Who is One Locus Mismatched sibling Donor, Who is not?

Abstract

The most important factor in donor-recipient matching for hematopoietic stem cell transplantation is their HLA typing. For many patients, we can not find a full-matched donor. In high risk patients, one locus  mismatched related donors are suitable alternatives. (1, 2) Since the matching of patients and their siblings usually is based on low resolution HLA typing, the matching of one locus mismatched  siblings is always prone to catastrophic errors.   The following cases clearly demonstrate the possible pitfalls and highlight the importance of the HLA typing of parents in the matching of patients and their full-matched and one locus, mismatched siblings.

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Teshima T, Matsuo K, Matsue K, et al. Impact of human leucocyte antigen mismatch on graft-versus-host disease and graft failure after reduced intensity conditioning allogeneic haematopoietic stem cell transplantation from related donors. Br J Haematol. 2005;130(4):575-87.

Weisdorf D, Spellman S, Haagenson M, et al. Classification of HLA-matching for retrospective analysis of unrelated donor transplantation: revised definitions to predict survival. Biol. Blood Marrow Transplant. 2008; 14(7):748-58.

European Federation for Immunogenetics. European Federation for Immunogenetics. [monograph on the Internet]. 2008 [cited 2009 Sep 3]. Available from: http://www.efiweb.eu/fileadmin/user/EFI_Standards_version_ 5.6.pdf.

Lee SJ, Klein J, Haagenson M, et al. High-resolution donorrecipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood. 2007;110(13):4576-83. Epub 2007 Sep

Grundschober C, Rufer N, Sanchez-Mazas A, et al. Molecular characterization of HLA-C incompatibilities in HLA-ABDR-matched unrelated bone marrow donor-recipient pairs. Sequence of two new Cw alleles (Cw*02023 and Cw*0707) and recognition by cytotoxic T lymphocytes. Tissue Antigens. 1997;49(6):612-23.

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IssueVol 3, No 3 (2009) QRcode
SectionArticles
Keywords
stem cell transplantation one locus mismatch sibling donor
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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Ostadali M, Ghashghaie A, Ghavamzadeh A. Who is One Locus Mismatched sibling Donor, Who is not?. Int J Hematol Oncol Stem Cell Res. 1;3(3):34-36.