Dual JAK1 and JAK2 Mutations in Philadelphia Chromosome–Like ALL: A Case Report and the Impact of Implementing NGS in a Resource- Limited Setting
Ph-like acute lymphoblastic leukemia with JAK1 and JAK2 mutations
-
David Garrido
,
Gabriela Jaramillo-Koupermann
,
Gabriela Galvez
,
Anahis Rebolledo
,
Maria del Carmen Trujillo
Abstract
None
1. Pui CH, Roberts KG, Yang JJ, et al. Philadelphia chromosome–like acute lymphoblastic leukemia. Clin Lymphoma Myeloma Leuk. 2017; 17(8):464-70.
2. Tran TH, Tasian SK. Has Ph-like ALL superseded Ph+ ALL as the least favorable subtype?. Best Pract Res Clin Haematol. 2021; 34(4):101331.
3. Mokhtar Ahmed A, Ibrahem Ahmad E, Gawish H, et al. Study of Philadelphia like acute lymphoblastic leukemia in adult patients using CRLF2 expression and JAK2 r683 mutation. Zagazig Univ Med J. 2025; 31(8):4169-78.
4. Frisch A, Ofran Y. How I diagnose and manage Philadelphia chromosome–like acute lymphoblastic leukemia. Haematologica. 2019; 104(11):2135-43.
5. Wu QY, Guo HY, Li F, et al. Disruption of E627 and R683 interaction is responsible for B-cell acute lymphoblastic leukemia caused by JAK2 R683G(S) mutations. Leuk Lymphoma. 2013; 54(12):2693-700.
2. Tran TH, Tasian SK. Has Ph-like ALL superseded Ph+ ALL as the least favorable subtype?. Best Pract Res Clin Haematol. 2021; 34(4):101331.
3. Mokhtar Ahmed A, Ibrahem Ahmad E, Gawish H, et al. Study of Philadelphia like acute lymphoblastic leukemia in adult patients using CRLF2 expression and JAK2 r683 mutation. Zagazig Univ Med J. 2025; 31(8):4169-78.
4. Frisch A, Ofran Y. How I diagnose and manage Philadelphia chromosome–like acute lymphoblastic leukemia. Haematologica. 2019; 104(11):2135-43.
5. Wu QY, Guo HY, Li F, et al. Disruption of E627 and R683 interaction is responsible for B-cell acute lymphoblastic leukemia caused by JAK2 R683G(S) mutations. Leuk Lymphoma. 2013; 54(12):2693-700.
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| Issue | Vol 20 No 3 (2026) | |
| Section | Editorial | |
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How to Cite
1.
Garrido D, Jaramillo-Koupermann G, Galvez G, Rebolledo A, Trujillo M. Dual JAK1 and JAK2 Mutations in Philadelphia Chromosome–Like ALL: A Case Report and the Impact of Implementing NGS in a Resource- Limited Setting. Int J Hematol Oncol Stem Cell Res. 2026;20(3):352-354.
