Left Ventricular Diastolic and Systolic Performance: A Study Using Tei Index in Adulthood Patients with Thalassemia Major

Abstract

Introduction: Cardiac complications, including heart failure, are the most important secondary ones of the thalassemia major disease, which manifests itself in adolescence and early adulthood. Appropriate, low cost diagnostic tools available as well as knowing its related factors are the most important components of therapy in these patients, given the importance of these complications, or by examining and revealing early symptoms. Thus, in this study, we intend to examine the systolic and diastolic ventricular effects in adult patients with the help of Tei index.
Methods: 70 adult patients with thalassemia major were examined in this study. Frequency of Tei index and its association with factors such as age, sex, level of packed cell injection, as well as hemosiderosis were measured in two blood levels of more than 1000 ferretins.
Results: In this study, 70 youth adult patients with thalassemia major with an average age of 21.3± 2.8 years were studied, 31 were male (44.4%). Tei index were abnormal in 16 patients (24%). There is no statistically significant correlation between the Tei index and one of the variables of age, gender, number and duration of blood transfusion and deferoxamine, the hemoglobin level and the number of ferretins (P>0.05).
Discussion: Study on Tei index shows that many patients are subclinically involved in the disease before the onset of clinical symptoms of heart failure, the subject which raises the need for early diagnosis of the disease; and it seems that none of the demographic factors or factors related to disease cannot be considered as a main cause or warning of the disease; and the above results can be confirmed only on the basis of paraclinical tests.