Original Article

Trace elements (Se, Zn, and Cu) levels in patients with newly diagnosed acute leukemia


This study was conducted to evaluate serum trace elements level, selenium (Se), zinc (Zn), and copper (Cu) at the diagnosis of acute leukemia, and also if there is any difference in their serum levels among various subtypes of disease.
Subjects: Fifty newly-diagnosed acute leukemia patients before starting therapy and fifty healthy subjects were entered into the study.
Methods: Serum trace elements level was determined by atomic absorption spectrometry technique.
Results: Serum selenium and zinc levels were significantly lower in patients than in healthy subjects. The comparison of trace element levels in acute myeloid leukemia (AML) subtypes showed significant difference in Se levels between AML-M3 and AML-M5. There were no significant difference between Cu levels of patients and healthy subjects.
Conclusions: Low serum levels of Zn and Se in leukemia patients in this study can express the need for assessing the effect of improving trace elements status on patient`s overall survival. A difference in Se levels between subgroups of AML patients warrants further investigation with larger sample size.

Abu Baker M, Nazmus Sadat AFM, Lutfor Rahman M, Salahuddin Qusar MMA, Imamul Hug SM, Iqbal Hossain M et al. Serum trace elements in manic patients. Dhaka Uni.v J. Pharm. Sci. (2005) 4: 181-5.

Arthur JR, Beckett GJ. New metabolic roles for Selenium. Proc. Nutr. Soc. (1994) 53: 615-24.

Whanger PD. Selenium in the treatment of heavy metal poisoning and chemical carcinogenesis. J. Trace Elem. Electrolytes. Health. Dis. (1992) 6: 209-21.

Thomson CD. Assessment of requirements for selenium and adequacy of selenium status: a review. Eur J Clin Nutr. (2004) 58(3):391-402

Gupta S, Narang R, Krishnaswami K, Yadav S. Plasma Selenium level in cancer patients. Indian J. Cancer. (1994) 31:192-7.

Schrauzer G.N, White D.N, Schneider C.J. Cancer mortality correlation studies-IV: Associations with dietary intakes and blood levels of certain trace elements, notably se-antagonists. Bioinorg. Chem. (1977) 7: 35-56.

McConnell K.P. and Cooper B.J. Distribution of selenium in serum proteins and red blood cells after subcutaneous injection of sodium selenite containing radioselenium. J. Biol. Chem. (1950) 183: 459-66

Agarwal A, Khanna P, Baidya D.K, Arora M.K. Trace elements in critical illness. J Endocrinol Metab.( 2011) 1(2):57-63

Çavdar AO, Ünal E, Babacan E, Gözdaşoğlu S, Yavuz G, Mengübaş K et al. Trace element analysis (zinc and selenium) in pediatric malignant lymphomas. Turk J. Haematol. (2002) 19: 239-44.

Harris ED. Regulation of antioxidant enzymes. FASEB J. (1992) 6: 2675-83.

Zuo XL, Chen JM, Zhou X, Li XZ, Mei GY. Levels of selenium, zinc, copper, and antioxidant enzyme activity in patients with leukemia. Biol. Trace .Elem .Res. (2006) 114: 41-53.

Beguin Y, Brasseur F, Weber G, Bury J, Delbrouck JM, Roelandts I et al. Observations of serum trace elements in chronic lymphocytic leukemia. Cancer. (1987) 60: 1842-6.

Navarro Silvera SA, Rohan TE. Trace elements and cancer risk: a review of the epidemiologic evidence. Cancer causes control. (2007) 18: 7-27.

Mumtaz M, Siddique A, Mukhtar N, Mehboob T. Status of trace elements level in blood samples of different age population of Karachi (Pakistan). Tr J. Med. Sci. (1999) 29: 697-9.

Hadjibabaie M, Iravani M, Shamshiri AR, Zaker Z, Mousavi A, Alimoghaddam K et al. The prevalence of low Selenium levels in adult patients undergoing bone marrow transplantation: A brief communication. Nutr. Cancer. (2008) 60: 837-9.

Johannessen JK, Gammelgaard B, Jons O, Hansen SH. Comparison of chemical modifiers for simultaneous determination of different selenium compounds in serum and urine by Zeeman-effect electrothermal atomic absorption spectrometry. J. Anal. At. Spectrom. (1993) 8: 999-1004.

Lipinski B. Rationale for the treatment of cancer with sodium selenite. Med. Hypotheses. (2005) 64: 806-10.

Safaralizadeh R, Kardar GA, Pourpak Z, Moin M, Zare A, Teimourian S. Serum concentration of selenium in healthy individuals living in Tehran. Neutr J. (2005)14; 4: 32.

Pazirandeh A, Assadi Nejad M, Vossogh P. Determination of selenium in blood serum of children with acute leukemia and effect of chemotherapy on serum selenium level. J. Trace. Elem. Med. Biol. (1999) 13: 242-6.

Asfour IA, El-Kholy NM, Ayoub MS, Ahmed MB, Bakarman AA. Selenium and glutathione peroxidase status in adult Egyptian patients with acute myeloid leukemia. Boil. Trace. Elem. Res. (2009) 132: 85-92.

Ringstad J, Jacobsen BK, Thomassen Y. The Tromsø Heart Study: relationships between the concentration of selenium in serum and risk factors for coronary heart disease. J. Trace. Elem. Electrolytes. Health. Dis. (1987) 1: 27-31.

Mcmaster D, Bell N, Anderson P, Love AHG. Automated measurement of two indicators of human selenium status, and applicability to population studies. Clin Chem. (1990) 36: 211-16.

Sullivan JF, Blotcky AJ, Jetton MM, Hahn HK, Burch RE. Serum levels of selenium, calcium, copper, magnesium, manganese and zinc in various human diseases. J. Nutr. (1979) 109: 1432-7.

Pink L, Gabriel P. Zinc and immune system. Proc. Nutr. Soc. (2000) 59: 541-52.

Dardenne M. Zinc and immune function. Eur J. Clin. Nutr. (2002) 56 suppl 3: S20-23.

Keen CL, Gershvin ME. Zinc deficiency and immune function. Annu. Rev. Nutr. (1990) 10: 415-431.

Wen CG, Pang GY, Huang SQ. Significance of the serum level of Cu, Zn, Mn, Cr, And Ni in acute leukemia. Zhonghua Nei Ke Za Zhi [Chinese journal of internal medicine]. (1989) 28: 734-6, 768-9.

Gurses S, Ulya AM, Feride D, Dilek B, Nazmiye Y. High prevalence of chronic magnesium deficiency in T cell lymphoblastic leukemia and chronic zinc deficiency in children with acute lymphoblastic leukemia and malignant lymphoma. Leuk. Lymph. (2000) 39: 555-62.

Harrison MD, Jones CE, Solioz M, Dameron CT. Intracellular copper routing: The role of copper chaperones. Trends. Biochem. Sci. (2000) 25: 29-32.

Çaglayan O, Aydog Y.Ş. Serum zinc and copper levels in rheumatoid arthritis. J. Islam. Acad. Sci. (1997) 10: 19-24.

Arnbjörnsson E, Abdulla M. Correlation between copper, zinc and ceruloplasmin in plasma of patients admitted for acote abdomen. Acta Pharmacologica et Toxicologica. (2009) 59: 180-3.

Deagen JT, Beilstein MA, Whanger PD. Chemical forms of selenium in selenium containing proteins from human plasma. J. Inorg. Bio-Chem. (1991) 41: 261-8.

Broghamer WLJr, McConnell KP, Grimaldi M, Blotcky AJ. Serum selenium and reticuloendothelial tumors. Cancer. (1978) 41: 1462-6.

Robinson MF, Godfrey PJ, Thomson CD, Rea HM, Van Rij AM. Blood selenium and glutathione peroxidase activity in normal subjects and in surgical patients with and without cancer in Newzealand. Am. J. Clin. Nutr. (1979) 32: 1477-85.

Fex G, Pettersson B, Akesson B. Low plasma selenium as a risk factor for cancer death in middle-aged men. Nutr. Cancer. (1987) 10: 221-9.

IssueVol 6, No 4 (2012) QRcode
SectionOriginal Article(s)
Acute leukemia Antioxidants Trace elements Selenium Zinc Copper

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How to Cite
Modaressi A, Hadjibabaie M, Shamshiri A, Namdar R, Abdollahi M, Ghavamzadeh A. Trace elements (Se, Zn, and Cu) levels in patients with newly diagnosed acute leukemia. Int J Hematol Oncol Stem Cell Res. 2015;6(4):5 - 10.