Concentration Study of High Sensitive C - reactive Protein and some Serum Trace Elements in Patients with Benign and Malignant Breast Tumor
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Abstract
Background: Breast cancer is the most common invasive cancer in females worldwide. It accounts for 16% of all female cancers and 22.9% of invasive cancers in women. 18.2% of all cancer deaths worldwide including both males and females are from breast cancer. In this study we compared few serum elements in patients with benign and malignant breast tumor to find any related prognostic and predictive value.
Subjects and Methods: A case-control study was carried out in a hospital (Tehran - Iran) in 2012. Target population was divided in 2 groups; subjects with benign and malignant breast tumors. We did preoperative hematological test. Five milliliter fasting blood vein was collected, centrifuged in 3000 g for 15 minutes to obtain serum. We measured serum Calcium (Ca), Phosphorus (P), Magnesium (Mg), Zinc (Zn), and high sensitive-CRP, analyzed statistically and compared recorded elements in 2 groups by software package SPSS version 16. The level of significant was considered P < 0.05.
Results: Of 87 women, 49 cases with benign breast disease (group A) and 38 cases with breast cancer (group B) entered our study. Serum concentration of Ca, mg, and P in group A were higher than group B, however these differences were not significant. We found no significant correlation between serum Zn and type of tumor in our patients. On the other hand, a significant elevation in hs-CRP in patient with breast cancer was seen (P Value=.000).
Conclusion: Our results have shown similar concentration of Ca, Mg, Zn, P and completely different hs-CRP concentration in patients with benign and malignant breast disease.
Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013.CA Cancer J Clin. 2013; 63(1):11-30.
Silva MP, Soave DF, Ribeiro-Silva A, et al. Trace elements as tumor biomarkers and prognostic factors in breast cancer: a study through energy dispersive x-ray fluorescence. BMC Res Notes. 2012 Jul 6; 5:194.
Magalhãesa T, Beckerb M, Carvalhoa ML, et al. Study of Br, Zn, Cu and Fe concentrations in healthy and cancer breast tissues by TXRF. Spectrochimica Acta Part B: Atomic Spectroscopy. 2008; 63(12): 1473–79.
Magalhães T, Carvalho ML, Von Bohlen A, et al. Study on trace elements behaviour in cancerous and healthy tissues of colon, breast and stomach: Total reflection X-ray fluorescence applications. Spectrochimica Acta Part B: Atomic Spectroscopy. 2010; 65(6): 493–8.
Carvalho ML, Magalhães T, Becker M, et al. Trace elements in human cancerous and healthy tissues: A comparative study by EDXRF, TXRF, synchrotron radiation and PIXE. Spectrochimica Acta Part B: Atomic Spectroscopy. 2007; 62(9):1004–11.
Rehman S, Husnain SM. A probable risk factor of female breast cancer: study on benign and malignant breast tissue samples. Biol Trace Elem Res. 2014; 157(1):24-9.
Yigit E, Gönüllü G, Yücel I, et al. Relation between hemostatic parameters and prognostic/predictive factors in breast cancer. Eur J Intern Med. 2008; 19(8):602-7.
Algarra M, Gomes D, Joaquim C.G, et al. Current analytical strategies for C-reactive protein quantification in blood Clinica Chimica Acta. 2013; 415(16):1–9.
Prins Rc, Rademacher BL, Mongoue-Tchokote S, et al. C-reactive protein as an adverse prognostic marker for men with castration-resistant prostate cancer (CRPC): Confirmatory results Urologic Oncology: Seminars and Original Investigations. 2012; 30(1):33–37.
Lee M, Lee D, Jung S, et al. Measurements of serum C-reactive protein levels in patients with gastric cancer and quantification using silicon nanowire arrays. Nanomedicine. 2010; 6(1):78-83.
Pierce B, Ballard-Barbash R, Bernstein L, et al. Elevated Biomarkers of Inflammation Are Associated With Reduced Survival Among Breast Cancer Patients. J Clin Oncol. 2009; 27(21):3437-44.
Huang Y, Sheu J, Lin T. Association between oxidative stress and changes of trace elements in patients with breast cancer. Clin Biochem. 1999 Mar; 32(2):131-6.
Sahmoun AE, Singh BB. Does a higher ratio of serum calcium to magnesium increase the risk for postmenopausal breast cancer? Med Hypotheses. 2010 Sep; 75(3):315-8.
Siddiqui MK, Singh S, Mehrotra PK, et al. Comparison of some trace elements concentration in blood, tumor free breast and tumor tissues of women with benign and malignant breast lesions: an Indian study. Environ Int. 2006; 32(5):630-7.
Sprague B, Skinner H, Trentham-Dietz A, et al. Serum Calcium and Breast Cancer Risk in a Prospective Cohort Study. Ann Epidemiol. 2010 Jan; 20(1):82-5.
Papaloucas CD, Papaloucas MD, Kouloulias V, et al. Measurement of blood phosphorus: A quick and inexpensive method for detection of the existence of cancer in the body. Too good to be true, or forgotten knowledge of the past? Med Hypotheses. 2014 Jan; 82(1):24-5.
FB de Jorge, JS Goes, JL Guedes. Biochemical studies on copper, copper oxidase, magnesium, sulfur, calcium and phosphorus in cancer of the breast Clinica Chimica Acta. 1965; 12(4):403–6.
Seltzer MH, Rosato FE, Fletcher Mj. Serum and tissue magnesium levels in human breast carcinoma. J Surg Res. 1970; 10(4):159-62.
Pasha Q, Malik SA, Shah MS. Statistical analysis of trace metals in the plasma of cancer patients versus controls. J Hazard Mater. 2008 30; 153(3):1215-21.
Allin KH, Nordestgaard BG, Flyger H, et al. Elevated pre-treatment levels of plasma C-reactive protein are associated with poor prognosis after breast cancer: a cohort study. Breast Cancer Res. 2011 3; 13(3):R55.
Tibau A, Ennis M, Goodwin P. Post-surgical highly sensitive C-reactive protein and prognosis in early-stage breast cancer. Breast Cancer Res Treat. 2013; 141(3):485-93.
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| Issue | Vol 9, No 4 (2015) | |
| Section | Articles | |
| Keywords | ||
| Benign and Malignant breast tumor hs-CRP Trace element | ||
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