Erythrocyte indices in Pre-school Nigerian Children with Sickle Cell Anaemia in Steady State
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Abstract
Sickle cell disease is a genetic haemoglobinopathy with consequent haemolysis and anaemia. It is of interest to study its effect on red cell indices beside haemoglobin concentration.The objective of the study is to determine the values of red cell indices in preschool-age children with sickle cell anaemia.we conducted a cross-sectional study including 97 children with sickle cell anaemia aged six months to five years and 97 age-and sex-matched healthy controls with haemoglobin genotype AA (Hb AA). The red cell indices such as packed cell volume, haemoglobin concentration, mean corpuscular volume, red blood cell count, mean corpuscular haemoglobin and mean corpuscular haemoglobin concentration were investigated, using an auto analyzer.The mean PCV, haemoglobin concentration and red blood cell count were significantly higher in HbAA controls (p = 0.000 in each case). The mean MCV was higher among HbSS subjects but it was only among females and when the result was analyzed irrespective of gender that the difference was statistically significant (p < 0.05).Children with sickle cell anaemia in steady state have lower values of all red cell parameters and higher values of MCV, compared to haemoglobin phenotype AA controls.
Serjeant GR, Serjeant BE. Sickle cell disease. 3rd ed. New York: Oxford University Press; 2001.
Adekile AD, Adeodu OO. Haemoglobinopathies. In: Azubuike JC, Nkanginieme KEO (editors). Textbook of Paediatrics and Child Health in a Tropical Region. 2nd ed. Owerri: African Educational Services; 2007. 373 - 90.
Usman S, Saiful FB, DiNatale J, et al. beating heart aortic valve replacement in a sickle cell patient. Interact Cardiovasc Thorac Surg 2010; 10: 67 – 8.
Awotua-Efebo O, Alikor EAO, Nkanginieme KEO. Malaria parasite density and splenic status by ultrasonography in stable sickle cell anaemia (HbSS) children. Nig J Med 2004; 13: 40 - 3.
Oyedeji GA. Socio-economic and cultural background of hospitalized children in Ilesha. Nig J Paediatr 1985; 12: 111 - 7.
Oredugba FA, Savage KO. Anthropometric findings in Nigerian children with sickle cell disease. Paediat Dent 2002; 24: 321 – 5.
Singhal A, Morris J, Thomas P, et al. Factors affecting prepubertal growth in homozygous sickle cell disease. Arch Dis child 1996; 74: 502 – 6.
Diagne I, Ndiaye O, Moreira C, et al. Sickle cell disease in children in Dakar, Senegal. Arch Pediatrie 2000; 7: 16 – 24.
Rahimy M, Gangbo A, Ahouignan G, et al. Effect of a comprehensive clinical care program on disease course in severely ill children with sickle cell anemia in a sub-Saharan African setting. Blood 2003; 102: 834 – 8.
Serjeant GR, Grandison Y, Lowrie Y, et al. The development of haematological changes in homozygous sickle cell disease: a cohort study from birth to 6 years. Br J Haematol 1981; 48: 533 – 43.
Thomas PW, Higgs DR, Serjeant GR. Benign clinical course in homozygous sickle cell disease: a search for predictors. J Clin Epidemiol 1997; 50: 121 – 6.
Miller S, Sleeper L, Pegelow C, et al. Prediction of adverse outcomes in children with sickle cell disease. N Engl J med 2000; 342: 83 – 9.
Quinn C, Ahmad N. Clinical correlates of steady-state oxyhaemoglobin desaturation in children who have sickle cell disease. Br J Haematol 2005; 131: 129 – 34.
Desai MR, Terlouw DJ, Kwena AM, et al. Factors associated with haemoglobin concentrations in pre-school children in Western Kenya: Cross-sectional studies. Am J Trop Med Hyg 2005; 72: 47 – 59
Jeyakumar LH, Akpanyung EO, Akenyemi AA, et al. An Investigation into the Iron Status of Children with Sickle-Cell Disease in Western Nigeria. J Trop Pediatr 1987; 33: 326 – 8
Khan Y, Thakur AS, Mehta R, et al. Hematological profile of sickle cell disease: a hospital based study at Cims, Bilaspur, Chhattisgarh. IJABPT 2010; 1: 717 – 21
Diop S, Thiam D, Cisse M, et al. New results in clinical severity of homozygous sickle cell anemia, in Dakar, Senegal. Hematol Cell Ther 1999; 41: 217 – 21.
Mouele R, Boukila V, Fourcade V,et al. Sickle-cell disease in Brazzaville, Congo: genetical, hematological, biochemical and clinical aspects. Acta Haematol 1999; 101: 178 – 84
Omoti CE. Haematological values in sickle cell anaemia in steady state and during vaso-occlusive crisis in Benin City, Nigeria. Ann Afr Med 2005; 4: 62 – 7.
Provan D. Mechanisms and management of iron deficiency anaemia. Br J Haematol 1999;105 Suppl 1:19 - 26
Mohanty D, Mukherjee MB, Colah RB, et al. Iron deficiency anaemia in sickle cell disorders in India. Indian J Med Res 2008; 127: 366 – 9
Bain BJ. Diagnosis from the Blood Smear. N Engl J med 2005; 353: 498 – 507
Temiye EO, Duke ES, Owolabi MA, et al. Relationship between Painful Crisis and Serum Zinc Level in Children with Sickle Cell Anaemia. Anaemia 2010 (cited 2014 April 23).Available from: http://www.hindawi.com/journals/ane/2011/69856
| Files | ||
| Issue | Vol 9, No 1 (2015) | |
| Section | Articles | |
| Keywords | ||
| Peripheral smear Red cell count Red cell indices Sickle cell anaemia Steady state | ||
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