Anemia and Thrombocytopenia in Acute and Chronic Renal Failure
Background: Acute renal failure describes as a syndrome by rapid decline in the ability of the kidney to eliminate waste products, regulate acid–base balance, and manage water homeostasis. When this impairment is prolonged and entered chronic phase, erythropoietin secretion by this organ is decreasing and toxic metabolic accumulates and causes hematological changes include decrease of HCT, MCV and RBC and platelet counts. This study evaluates present of anemia and thrombocytopenia in patients with acute and chronic renal failure.
Materials and Methods: This study conducted on 132 patients with renal impairment and also 179 healthy individuals as two separated control groups. Initially patients with renal problem were tested and after confirmation of impairment, patients were divided in two groups, acute with less than 3 months and chronic with more than 3 months renal failure, based on duration of the disease. Then complete blood count performed for each patient and finally obtained data were analyzed by SPSS software.
Results: Comparison between 96 patients with acute and 36 patients with chronic renal failure revealed that severity of anemia (HCT, Hb and MCV) between these two groups were statistically high in comparison with control groups (P>0.05) but thrombocytopenia in patients with chronic renal failure was statistically different from control and the acute ones (P<0.001).
Conclusion: It was recommended that in patients with chronic renal failure, to prevent the risk of bleeding, platelet count should be checked periodically.
Prasad N, Barai S, Gambhir S, Parasar D, Ora M, Gupta A, et al. Comparison of glomerular filtration rate estimated by plasma clearance method with modification of diet in renal disease prediction equation and Gates method. Indian Journal of Nephrology. 2012;22(2):103.
Russell CD, Bischoff PG, Kontzen FN, Rowell KL, Yester MV, Lloyd LK, et al. Measurement of glomerular filtration rate: single injection plasma clearance method without urine collection. Journal of nuclear medicine: official publication, Society of Nuclear Medicine. 1985;26(11):1243.
Haller M, Schelling G. Acute kidney failure. Physiopathology--clinical diagnosis--therapy]. Der Anaesthesist. 2000;49(4):349.
Star RA. Treatment of acute renal failure. Kidney international. 1998;54(6):1817-31.
Thadhani R, Pascual M, Bonventre JV. Acute Renal Failure. New England Journal of Medicine. 1996;334(22):1448-60.
Dor A, Pauly M, Eichleay MA, Held PJ. End-stage renal disease and economic incentives: the international study of health care organization and financing. National Bureau of Economic Research Cambridge, Mass., USA; 2007.
Park J. Cardiovascular Risk in Chronic Kidney Disease: Role of the Sympathetic Nervous System. Cardiology Research and Practice. 2012;2012.
Haroun MK, Jaar BG, Hoffman SC, Comstock GW, Klag MJ, Coresh J. Risk factors for chronic kidney disease: a prospective study of 23,534 men and women in Washington County, Maryland. Journal of the American Society of Nephrology. 2003;14(11):2934-41.
Saucier NA, Sinha MK, Liang KV, Krambeck AE, Weaver AL, Bergstralh EJ, et al. Risk factors for CKD in persons with kidney stones: a case-control study in Olmsted County, Minnesota. American Journal of Kidney Diseases. 2010;55(1):61-8.
Vincent J-L, Zapatero DC. The role of hypotension in the development of acute renal failure. Nephrology Dialysis Transplantation. 2009 February 1, 2009;24(2):337-8.
Radtke HW, Claussner A, Erbes PM, Scheuermann EH, Schoeppe W, Koch KM. Serum erythropoietin concentration in chronic renal failure: relationship to degree of anemia and excretory renal function. Blood. 1979;54(4):877-84.
Hales M, Solez K, Kjellstrand C. The anemia of acute renal failure: association with oliguria and elevated blood urea. Renal failure. 1994;16(1):125-31.
Gafter U, Bessler H, Malachi T, Zevin D, Djaldetti M, Levi J. Platelet count and thrombopoietic activity in patients with chronic renal failure. Nephron. 1987;45(3):207-10.McClellan W, Aronoff SL, Bolton WK, Hood S, Lorber DL, Tang KL, et al.
McClellan W, Aronoff SL, Bolton WK, Hood S, Lorber DL, Tang KL, et al. The prevalence of anemia in patients with chronic kidney disease. Current Medical Research and Opinion®. 2004;20(9):1501-10.
Mohamed NMB. Evaluation of Hemostatic Mechanism in Sudanese Renal Failure’s Patients Admitted to Khartoum Teaching Hospital College of Medical Laboratory Science. 2010-01-01
|Issue||Vol 7, No 4 (2013)|
|Acute renal failure Anemia Chronic renal failure Thrombocytopenia|
|Rights and permissions|
|This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.|